BACKGROUND AND PURPOSE Epidermal growth factor receptor amplification is a common molecular event in glioblastomas. The purpose of this study was to examine the potential usefulness of morphologic and diffusion MR imaging signs in the prediction of epidermal growth factor receptor gene amplification status in patients with glioblastoma. MATERIALS AND METHODS We analyzed pretreatment MR imagin...

Purpose: This study aimed to evaluate the relationship between strain elastography and immunohistochemical markers, histologic grade, molecular subtyping in invasive breast cancer.
 Materials Methods: The relationships index values progesterone receptor, estrogen human epidermal growth factor receptor 2, Ki-67, subtype 171 patients who had not received neoadjuvant treatment underwent breas...

Abbreviations: PI3K-Akt: Phosphatidylinositol-3-Kinase and Protein Kinase B; Rac1: Ras-Related C3 Botulinum Toxin Substrate 1; LN332: Laminin 332; EGF: Epidermal Growth Factor; EGF-R: Epidermal Growth Factor Receptor; IGF1&IGF-II: Insulin-Like Growth Factor 1&2; Gtpase: Guanosine 5’-Triphosphate Hydrolase Enzyme; IRS-1, IRS-2: Insulin Receptor Substrate 1&2; ERK: Extracellular Receptor Kinase; ...

Contemporary advancements have had little impact on the treatment of gastric cancer (GC), the world's second highest cause of cancer death. Agents targeting human epidermal growth factor receptor mediated pathways have been a common topic of contemporary cancer research, including monoclonal antibodies (mAbs) and receptor tyrosine kinase inhibitors (TKIs). Trastuzumab is the first target agent ...

Abbreviations: PI3K-Akt: Phosphatidylinositol-3-Kinase and Protein Kinase B; Rac1: Ras-Related C3 Botulinum Toxin Substrate 1; LN332: Laminin 332; EGF: Epidermal Growth Factor; EGF-R: Epidermal Growth Factor Receptor; IGF1&IGF-II: Insulin-Like Growth Factor 1&2; Gtpase: Guanosine 5’-Triphosphate Hydrolase Enzyme; IRS-1, IRS-2: Insulin Receptor Substrate 1&2; ERK: Extracellular Receptor Kinase; ...

Signaling pathways mediated by receptor tyrosine kinases (RTKs) and their ligands play important roles in the development and progression of human cancers, which makes RTK-mediated signaling pathways promising therapeutic targets in the treatment of cancer. Compared with small-molecule compounds, antibody-based therapeutics can more specifically recognize and bind to ligands and RTKs. Several a...