BACKGROUND Hyperglycemia-mediated oxidative stress implicates in etiology of kidney cell aging and diabetic nephropathy. We evaluated the effects of different doses of resveratrol and quercetin and their combination therapy on aging marker in human kidney cell culture under hyperglycemia condition. METHODS Human embryonic kidney cell (HEK-293) was cultured in Dulbecco's Modified Eagle Medium ...

In a systematic effort to identify a potent antiproliferative agent, four complexes of vanadium containing maltol and deferiprone ligands were synthesized and evaluated for their cytotoxic activity against five human and animal cancer cell lines, including human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line ...

The present study investigates the anti-proliferative and apoptosis inducing mechanism of CoCl2·6H2O in PC-3 cancer cell line. Preliminary, three different forms of cobalt i.e., cobaltous (CoCl2·6H2O), macro-Co(II,III) oxide and nano-Co(II,III) oxide were screened for antiproliferative activity in PC-3 cell line. The CoCl2·6H2O being the most effective antiproliferative agent, hence it was furt...

the objective of the study was to evaluate the cytotoxic effects of aqueous extract of cucumis melo fruit on human prostate cancer cell line (pc-3) using mtt and neutral red assays. the crude aqueous extract of c. melo was prepared by cold maceration method, filtered, concentrated and tested on pc-3 cell line. dose-dependent cytotoxic activities were exhibited on human prostate carcinoma pc-3 c...

Virus particles morphologically similar to the known oncogenic RNA-type viruses have been isolated and cultured from a spontaneous mammary carcinoma of a rhesus monkey. The virus was initially isolated by cocultivation of tumor tis sues with monkey embryonic cell cultures but was later found to be transmissible as a cell-free filtrate. The virus is approximately 110 m^t in diameter and has a bu...

cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. it has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior of variety of breast cancer cell lines. in spite of few investigations, there is a controversy in the literatures about the effects of adipocyte...

Mammalian Gastrin Releasing Peptide (GRP) has a widespread distribution and multiple stimulating effects on metabolism, release of regulatory peptides, gastrointestinal and pancreatic secretions, and behaviour. GRP is a potent mitogen for a number of tumor types including colon and lung. Although GRP is known to stimulate the growth of renal tumors, little is known of its synthesis, distributio...

abstract ethanol has a vast consumption around the world. many researches confirmed some adverse effect of this component on human health. in addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (hfff2) in the specific dosage of ethanol. here, the role and interaction of some proteins (characterized by sig...

background: in spermatogenesis, spermatogonial cells differentiate to the haploid gametes. it has been shown that spermatogenesis can be done at in vitro condition. in vitro spermatogenesis may provide an open window to treat male infertility. objective: the aim of this study was to evaluate the effects of a novel scaffold containing human serum albumin (hsa)/tri calcium phosphate nanoparticles...