The role of surgery in the treatment of patients with metastatic choriocarcinoma has diminished. We present a case of chemo-resistant metastatic choriocarcinoma salvaged by surgery. A 48-year-old patient presented with uterine perforation and severe intractable hemorrhage, and histological examination revealed a choriocarcinoma. After 6 years of disease-free state, recurrence occurred in the re...

In this study, for the first time, a simple immunosensor for ultrasensitive recognition of Human Chorionic Gonadotropin (hCG) in serum samples was fabricated by exploiting a simple approach. In this method, a low-cost and sensitive immunosensor was fabricated based on QDs-N-S/Au nanoparticles (NPs) modified Screen-Printed Carbon Electrode (SPCE). It seems that, QDs-N-S/Au NPs/ antibody as a bio...

Gonadotropins are routinely administered to produce multiple oocytes for clinical in vitro fertilization (IVF) treatment, laboratory research, and livestock industries. Studies in mice have shown gonadotropin stimulation using equine chorionic gonadotropin (eCG) affects the endometrium, implantation, and fetal development. Evidence from clinical studies also indicates that stimulation with reco...

OBJECTIVE To analyze serial human chorionic gonadotropin (hCG) levels in women presenting to the emergency department who were ultimately confirmed to have ectopic pregnancies. METHODS Human chorionic gonadotropin levels were obtained over time until definitive diagnosis. To be included, women had to have at least 2 hCG measurements. Human chorionic gonadotropin curves were characterized and ...

This case describes an atypical presentation of molar pregnancy in an emergency department patient with abdominal pain and vaginal bleeding. The patient demonstrated clinical features of hydatidiform mole, including acute discharge of a large, grape-like vesicular mass, despite multiple negative urine pregnancy tests. These false-negative qualitative human chorionic gonadotropin assays were lik...

Choriocarcinoma is a highly invasive and metastatic neoplasm which arises in women of reproductive age. It can be either gestational or nongestational in origin, but the latter form is very rare. Choriocarcinoma is characterized by the production of human chorionic gonadotropin. It can metastasize to distant organs such as lung, brain, liver, kidney, and vagina in the early stages of disease, b...

Treatment with colchicine or x-radiation of a human embryonal carcinoma of testicular origin, which has secreted a chorionic gonadotropin-like hormone in ~0 per cent of heterografted hosts, resulted in a 2 89 times increase in the incidence of chorionic gonadotropin-secreting tumors as determined in oophorectomized and hypophysectomized animals. Lines developed from three of the tumors treated ...

3A2 is an antibody raised against human chorionic gonadotropin and recognizes a linear epitope on the C-terminal peptide of the human chorionic gonadotropin beta-subunit. Its three-dimensional structure has been determined to 2-A resolution using molecular replacement and refined to a conventional R-factor of 18.2%. The protein exhibits the typical immunoglobulin fold, and the model contains 94...

background: the direct effect of hcg on the human endometrium was studied several times. objective: the objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhcg) before embryo transfer (et). materials and methods: in this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoin...