The integration of applications (application-toapplication integration, A2AI) within an enterprise has the advantage that the applications to be integrated are within one enterprise, hence, within one domain of control. Consequently hub-and-spoke architectures are deployed that provide a common infrastructure for integration, namely, the exchange of data between applications. The applications d...

This paper studies the e ect of the airline industry's operational time-line on multi-market competition and carrier network structure selection. Airline carriers typically commit to a rigid capacity of seats via the planned ights schedule long before market competition for selling these seats begins. While in regular markets such a two stage setting has no e ect on competitive behavior, the ai...

BACKGROUND AND PURPOSE Acute stroke clinical trials are conducted primarily at academic medical centers. As a result, patients living in rural areas are excluded from participation, results may not be generalizable to nonacademic settings, and studies may be slow to recruit subjects. Telemedicine can provide rural patients with emergency neurovascular consultation. We sought to determine whethe...

The hub location problem is employed for many real applications, including delivery, airline and telecommunication systems and so on. This work investigates on hierarchical hub network in which a three-level network is developed. The central hubs are considered at the first level, at the second level, hubs are assumed which are allocated to central hubs and the remaining nodes are at the third ...

The nematode C. elegans senses head and nose touch using multiple classes of mechanoreceptor neurons that are electrically coupled through a network of gap junctions. Using in vivo neuroimaging, we have found that multidendritic nociceptors in the head respond to harsh touch throughout their receptive field but respond to gentle touch only at the tip of the nose. Whereas the harsh touch respons...

We introduce mesh networks as an alternative topology to hub-and-spoke for low-cost carriers (LCCs) sell online connections, i.e., indirect connections requiring a transfer between direct within carrier's own operated network. While common global practice, none of the large independent intra-European LCCs has fully deployed such network strategy. define point-to-point with (PPWOC) representatio...