ACROSS SEVERAL MAMMALIAN SPECIES, moderate to high intensity aerobic-type exercise consistently protects against experimental ischemia-reperfusion (IR) insults by mitigating IR-induced ventricular arrhythmias, pump dysfunction, and tissue death [see review (8)]. Collective understanding of exercise-induced cardioprotection against IR injury was significantly advanced by the observation that a f...

The purpose of the present study was 1) to develop a stable model for measuring contraction-induced elevations in mRNA in single skeletal muscle fibers and 2) to utilize this model to investigate the response of heat shock protein 72 (HSP72) mRNA following an acute bout of fatiguing contractions. Living, intact skeletal muscle fibers were microdissected from lumbrical muscle of Xenopus laevis a...

BACKGROUND Investigations following stroke first of all require information about the spatio-temporal dimension of the ischemic core as well as of perilesional and remote affected tissue. Here we systematically evaluated regions differently impaired by focal ischemia. METHODOLOGY/PRINCIPAL FINDINGS Wistar rats underwent a transient 30 or 120 min suture-occlusion of the middle cerebral artery ...

OBJECTIVE The aim of the study was to compare the effects of two different concentrations of cryoprotectants by cryotopvitrification on survival, developmental capacity and Heat shock protein 72 (Hsp72) expression of two-cell mouse embryos. MATERIALS AND METHODS In this experimental study, transcript analysis of Hsp72 gene was performed on non-vitrified and vitrified 2-cell mouse embryos via ...

PURPOSE To investigate whether heat shock protein (Hsp) 72 is induced in retinal ganglion cells (RGCs) in experimental rat glaucoma and whether the induction of Hsp72 by heat stress or zinc (Zn(2+)) administration can increase survival of RGCs in the model. METHODS Intraocular pressure (IOP) was elevated unilaterally in Wistar rats with argon laser irradiation of the trabecular meshwork 5 day...