1Tumor Immunology Program, Stanley S. Scott Cancer Center, Louisiana State University–Health Sciences Center (LSU-HSC), New Orleans; 2Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA; 3Department of Pediatrics, LSU-HSC, New Orleans; 4School of Public Health, Louisiana State University, New Orleans; 5Ochsner Clinic Foundation, New Orleans, LA; and 6Dep...

45 46 The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver 47 fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from 48 all causes. The molecular mechanisms driving HSC differentiation are not fully 49 understood. Because macroscopic tissue stiffening is a feature of fibrotic disease, we 50 hypothesized that mechan...

Abstract By using the subregion CV conjecture, we numerically investigate behavior of holographic complexity (HSC) and compare it with entanglement entropy (HEE) in unbalanced superconductors, which indicates that both HEE HSC can be used as good probes to phase transition superconductors. We observe exhibit a similar linear growth change width for strip geometry. However, different fixed width...

This study introduces, two models based on Gene Expression Programming (GEP) to predict compressive strength of high strength concrete (HSC). Composition of HSC was assumed simplified, as a mixture of six components (cement, silica fume, super-plastisizer, water, fine aggregate and coarse aggregate). The 28-day compressive strength value was considered the target of the prediction.  Data on 159...

Despite the numerous advantages of using concrete with high strength capacity, the brittle behavior of high strength concrete (HSC) and higher production cost has limited its use in the construction industry. This research aims to develop a cost-effective approach for production of high strength self-compacting concrete with desirable performance in either compressive or tensile loading conditi...

The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cells are considered a key target of cancer immune therapy, in vivo animal models allowing differentiation of human immunosuppressive myeloid cells ha...

BACKGROUND Previous studies have shown that the numbers of both circulating hematopoietic progenitor cell (HPC) and CD34(+) cell are positively correlated with CD34(+) cell harvest yield. However, the minimal numbers of both circulating HPCs and CD34(+) cells required for performing an efficient hematopoietic stem cell (HSC) harvest in lymphoma and myeloma patients have not been defined in our ...

Hepatic stellate cell (HSC) activation is a key event in the natural process of wound healing as well as in fibrosis development in liver. Current in vitro models for HSC activation contribute significantly to the understanding of HSC biology and fibrogenesis but still fall far short of recapitulating in vivo intercellular functional and anatomic relationships. In addition, when cultured on unc...

Hepatic stellate cells (HSC), the key fibrogenic cells of the liver, transdifferentiate into myofibroblasts upon phagocytosis of apoptotic hepatocytes. Galectin-3, a β-galactoside-binding lectin, is a regulator of the phagocytic process. In this study, our aim was to study the mechanism by which extracellular galectin-3 modulates HSC phagocytosis and activation. The role of galectin-3 in engulf...

Bone marrow hematopoietic stem cells (HSCs) are responsible for both lifelong daily maintenance of all blood cells and for repair after cell loss. Until recently the cellular mechanisms by which HSCs accomplish these two very different tasks remained an open question. Biological evidence has now been found for the existence of two related mouse HSC populations. First, a dormant HSC (d-HSC) popu...