نتایج جستجو برای: hsa denaturation

تعداد نتایج: 10128  

2017
Yingbo Hu Cheng Cheng Zhengdong Hong Ziming Shi

Bladder cancer is the most common malignant tumor of the urinary system, and it is also an important cause of death by cancer globally. Increasing number of studies have shown that miRNAs can be used as prognostic markers for cancers. This study made use of the data available in the Cancer Genome Atlas in order to statistically analyze reported expression levels of miRNAs in samples from bladde...

Journal: :The Journal of Experimental Medicine 1971
Robert C. Bast Blanche A. Simpson Harold F. Dvorak

Antigen-mediated stimulation of thymidine incorporation was demonstrated in lymph node cells from guinea pigs immunized with 100 microg human serum albumin in either Freund's incomplete or Freund's complete adjuvant. Animals receiving HSA in IFA exhibited both cutaneous basophil (Jones-Mote) hypersensitivity and lymphocyte stimulation at 1, but not at 6 wk after immunization. Significant stimul...

Journal: :Biophysical journal 2009
Zuojia Liu Xiliang Zheng Xiurong Yang Erkang Wang Jin Wang

The affinity and specificity of drugs with human serum albumin (HSA) are crucial factors influencing the bioactivity of drugs. To gain insight into the carrier function of HSA, the binding of levamlodipine with HSA has been investigated as a model system by a combined experimental and theoretical/computational approach. The fluorescence properties of HSA and the binding parameters of levamlodip...

2016
Jing Lu Hao Gu Qiuqin Tang Wei Wu Beilei Yuan Dan Guo Yongyue Wei Hong Sun Yankai Xia Hongjuan Ding Lingqing Hu Daozhen Chen Jiahao Sha Xinru Wang

MicroRNA plays an important role in spermatogenesis. Whether pre-miRNAs polymorphisms are associated with idiopathic male infertility remains obscure. In this study, 1378 idiopathic infertile males and 486 fertile controls were included between 2006 and 2014. Genotype of three polymorphisms (hsa-mir-146a rs2910164, hsa-mir-196a-2 rs11614913, and hsa-mir-499 rs3746444) and expression of miRNA in...

Journal: :Molecules 2016
Yi-Cun Chen Hong-Mei Wang Qing-Xia Niu Dan-Yan Ye Guo-Wu Liang

Saikosaponin C (SSC) is one of the major active constituents of dried Radix bupleuri root (Chaihu in Chinese) that has been widely used in China to treat a variety of conditions, such as liver disease, for many centuries. The binding of SSC to human serum albumin (HSA) was explored by fluorescence, circular dichroism (CD), UV-vis spectrophotometry, and molecular docking to understand both the p...

Journal: :Journal of photochemistry and photobiology. B, Biology 2008
Ajay Kumar Shaw Samir Kumar Pal

Human serum albumin (HSA) is a very important multi-domain transporter protein in the circulatory system responsible for carriage of various kinds of ligands within the physiological system. HSA is also known to undergo conformational transformation at different pH(s) and temperatures. In this report we have studied the binding interactions of a photosensitizing drug, protoporphyrin IX (PPIX) w...

2012
Ejaz Ahmad Gulam Rabbani Nida Zaidi Basir Ahmad Rizwan Hasan Khan

Structural changes in human serum albumin (HSA) induced by the pollutants 1-naphthol, 2-naphthol and 8-quinolinol were analyzed by circular dichroism, fluorescence spectroscopy and dynamic light scattering. The alteration in protein conformational stability was determined by helical content induction (from 55 to 75%) upon protein-pollutant interactions. Domain plasticity is responsible for the ...

2012
Mi-Sook Lee Jae-In Jung Seung-Hae Kwon Sang-Mok Lee Kyoji Morita Song Her

TIMP-2 protein has been intensively studied as a promising anticancer candidate agent, but the in vivo mechanism underlying its anticancer effect has not been clearly elucidated by previous works. In this study, we investigated the mechanism underlying the anti-tumor effects of a TIMP-2 fusion protein conjugated with human serum albumin (HSA/TIMP-2). Systemic administration of HSA/TIMP-2 effect...

2014
Navonil De Sarkar Roshni Roy Jit Kumar Mitra Sandip Ghose Arnab Chakraborty Ranjan Rashmi Paul Indranil Mukhopadhyay Bidyut Roy

Deregulation of miRNA expression may contribute to tumorigenesis and other patho-physiology associated with cancer. Using TLDA, expression of 762 miRNAs was checked in 18 pairs of gingivo buccal cancer-adjacent control tissues. Expression of significantly deregulated miRNAs was further validated in cancer and examined in two types of precancer (leukoplakia and lichen planus) tissues by primer-s...

2018
Meiqing Zhu Lijun Wang Yu Wang Jie Zhou Jie Ding Wei Li Yue Xin Shisuo Fan Zhen Wang Yi Wang

The herbicide atrazine is widely used across the globe, which is a great concern. To investigate its potential toxicity in the human body, human serum albumin (HSA) was selected as a model protein. The interaction between atrazine and HSA was investigated using steady-state fluorescence spectroscopy, synchronous fluorescence spectroscopy, UV-Vis spectroscopy, three-dimensional (3D) fluorescence...

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