Human papillomavirus (HPV) vaccines offer primary prevention of cervical cancer and protection against other HPV-associated cancers. HPV vaccine coverage in the United States (U.S.) remains low, particularly among older adolescents/young adults, and the uninsured. We assessed awareness and knowledge of HPV disease, HPV-related cancers, and HPV vaccines among working, uninsured adults. Data from...

conclusions the results showed remarkable rates of high-risk hpv types (16 and 18) in the studied population, which can be a serious alert for public health. this result highlights the potential impact of prophylactic vaccines for future protection against high-risk hpv types in iranian women. materials and methods this cross-sectional population-based study consisted of two groups of women: no...

Human papillomavirus (HPV)-related cancers are a major worldwide public health concern. Virtually all cervical cancer is HPV related, with 70% caused by HPV16 and -18. Variable proportions of certain noncervical cancers (e.g., anal, vulvar, and oropharyngeal) are HPV related; more than 90% of the HPV-related ones are caused by HPV16, -18. The HPV-related cancers are dominated by cervical cancer...

A novel approach for primary prevention of cervical cancer has become available by the discovery of efficient prophylactic human papillomavirus (HPV) vaccines based on virus-like particles. This review elaborates on the progress in the field of prophylactic HPV vaccination achieved in the past decade, provides indications for prophylactic HPV vaccination, and discusses the impact on public heal...

Much progress has been made in the prevention and therapy of premalignant and malignant dysplasia caused by human papillomavirus by encouraging screening programs and recently by introducing preventive vaccines. To further reduce the worldwide burden of HPV-associated cancer supplementation of the established therapies with immunotherapeutic methods would have the potential for significant impa...

INTRODUCTION To provide information for cervical cancer screening and vaccination in Henan province, China, the distribution of human papillomavirus (HPV) was analyzed. METHODS The HPV genotypes were detected using gene array and flow-through hybridization. RESULTS Overall, 38.1% (1,536/4,033) of the women were human papillomavirus deoxyribonucleic acid (HPV DNA) positive. The prevalence of...

Cervical cancer remains a medical and social problem for our country and requires the implementation of effective strategy for its prevention. The etiopathogenesis of precancer lesions and cervical cancer is associated with the human papillomavirus infection. The proof of the biological significance of papillomavirus infection led to the need to identify the role of individual HPV types, and th...

OBJECTIVE To compare costs and effectiveness of three strategies used against cervical cancer (CC) and genital warts: (i) Screening for CC; (ii) Bivalent Human Papillomavirus (HPV) 16/18 vaccine added to screening; (iii) Quadrivalent HPV 6/11/16/18 vaccine added to screening. METHODS A Markov model was designed in order to simulate the natural history of the disease from 12 years of age (vacc...

Human papillomavirus (HPV) infection is of much current interest, with the availability and increasing use of the vaccines in different localities including Hong Kong. In this issue of the Topical Update, Prof. Paul Chan shares the local epidemiology of cervical HPV infection, in aid of formulating strategies to maximize the clinical benefits and cost-effectiveness of HPV-based diagnostic tests...

Over 100 human papillomavirus (HPV) types have been identified to date, of which over 40 infect the genital tract, primarily through sexual transmission. The many different genital HPV types appear to infect, resolve, or persist, and cause abnormal cytology and cervical intraepithelial neoplasia. Several cofactors have been associated with HPV persistence and lesion progression, including smoki...