The objective of the present study was formulation and evaluation pulsatile release tablets Atenolol. A tablet system consisting cores which coated with layers swelling rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression appropriate ratios lactose microcrystalline cellulose then sequentially different an inner layer HPMC outer Ethyl Cellulose. effect...

The objective of this project was to improve the solubility poorly water soluble drugs, namely cefuroxime axetil by formulating solid dispersions with hydrophilic polymer. Hydroxypropyl methyl cellulose (HPMC), polyvinyl pyrrolidine (PVP) and polyethylene glycol (PEG) were used as polymeric carriers for preparation dispersion. Solid prepared solvent extraction method. Interaction effect HPMC, P...

Buccal matrices represent a widely accepted dosage form permitting convenient, easy, reliable drug administration and reducing errors. The aim of this study was the development mucoadhesive buccal for propranolol in children. Matrices were obtained by freeze-drying loaded polymeric solutions based on gum tragacanth (GT), pectin (PEC), hydroxypropylmethylcellulose (HPMC), sodium hyaluronate (HA)...

OBJECTIVE The continuous contact of glucose-containing peritoneal dialysis (PD) fluids with the peritoneum results in the intraperitoneal formation of early and advanced glycation end-products. This nonenzymatic glycation of proteins may cause morphological and functional alterations to the peritoneum, which may contribute to patient dropout from PD therapy. Because fibrinolytic system componen...

Metoprolol succinate (M.succinate), a BCS Class I drug is the most widely prescribed anti-hypertensive drug and is considered to be safe. Owing to its high solubility, fabrication of an extended release matrix formulation becomes extremely challenging. Hydrophilic matrix polymers are the preferred systems for developing an extended release formulation. However, for highly soluble drugs, it fail...

This study aimed to obtain site-specific and controlled drug release particulate systems. Some particulates were prepared using different concentrations of sodium alginate (Na-Alg) alone and others were formulated using different proportions of Na-Alg with hydroxypropyl methylcellulose (HPMC) stearoxy ether (60M viscosity grade), a hydrophobic form of conventional HPMC, using diclofenac potassi...

Edible films and coatings in foods can be used to increase shelf-life and improve organoleptic characteristics of foods by avoiding deterioration of food components and therefore promoting preservation of the final product. This study is the first to investigate the use of different size fillers for the purpose of preparing edible composite films with fillers < 1.0 microm in size. For this purp...

The influence of commonly used excipients, spray-dried lactose (SDL), microcrystalline cellulose (MCC), and partially pregelatinized maize starch (Starch 1500) on drug release from hydroxypropyl methylcellulose (HPMC, hypromellose) matrix system has been investigated. A model formulation contained 30%w/w drug, 20%w/w HPMC, 0.5%w/w fumed silica, 0.25%w/w magnesium stearate, and 49.25%w/w filler....

The objective of the present study was to develop floating microsphere of norfloxacin in order to achieve an extended retention in the upper GIT which may enhance the absorption and improve the bioavailability. The microspheres were prepared by solvent evaporation method using different ratio of hydroxyl propyl methyl cellulose (HPMC K4M, HPMC K15M) and ethyl cellulose with drug in the mixture ...