Recent experiments in our laboratory have revealed a genetic correlation of the sensitivity of inbred mouse strains to different assays of nociception using noxious heat stimuli. An open question is whether the property of the noxious stimulus underlying the genetic correlation is heat specifically or simply a temperature (hot or cold) in the noxious range. The existing electrophysiological, ps...

objective(s): the aim of study was to investigate the antinociceptive effect of intracerebroventricular (icv) microinjection of origanum vulgare (org) extract and possible involvement of opioid receptors.   materials and methods: cannula was inserted into left ventricle of male rats. five days after surgery tail flick latency (tfl) was measured after icv microinjection of, org (1, 3 and 6 μg / ...

BACKGROUND The oyster mushroom, Pleurotus ostreatus, is cultivated worldwide. It is one of the most appreciated mushrooms due to its high nutritional value. Immersion of the substrate in hot water is one of the most popular and worldwide treatment used for mushroom farmers. It is cheap and easy to implement. AIMS To compare the yields obtained during mushroom production of P. ostreatus using ...

Trichoderma spp is the cause of the green mold disease in mushroom cultivation production. Many disinfection treatments are commonly applied to lignocellulose substrates to prevent contamination. Mushroom growers are usually worried about the contaminations that may occur after these treatments during handling or spawning. The aim of this paper is to estimate the growth of the green mold Tricho...

Ten new synthetic thiazolidine-4-ones derivatives (5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones) having different substituents at R1, R2 and R3 were evaluated for their analgesic activity using different animal models and their structure activity relationship was also elucidated. Chlorothiazolidine-4-ones and methoxythiazolidine-4-ones exhibited anal...

introduction: the antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. one of the major components of this pathway is the nucleus raphe magnus (nrm). our previous study demonstrated the involvement of nrm in the analgesic effect of morphine microinjected into the nucleus cuneiformis (ncf) in a descending manner. the aim of the current study wa...

The influence of tiagabine at a dose of 3.2 mg/kg (single administration) and at a dose of 1.2 mg/kg (multiple administration - 10 days) on the antinociceptive effect of morphine (10 mg/kg), metamizole (500 mg/kg) and indomethacin (10 mg/kg - single dose and 1.4 mg/kg - multiple doses) was investigated in mice using the hot-plate and tail-flick tests. All drugs were injected intraperitoneally. ...

The selected parts of four medicinal plants, Achillea millefolium, Hibiscus rosasinensis, Linum usitatissimum and Pluchea lanceolata were extracted in absolute methanol to determine their analgesic activity. Analgesic activity was assessed on intact mice by tail flick latency via the tail immersion method. The analgesic activities of these plant extracts were compared with acetylsalicylic a...

the seeds of peganum harmala l. ( pgh ) (zygophyllaceae) have been used in moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process. the major objective of this paper was to investigate the analgesic effect of ethyl acetate (eae), butanolic (be) and aqueous (aqe) extracts of seeds of peganum harmala and elucided the possible underlying action mechanism o...