Schizophrenia is a complex disorder with polygenic inheritance. The MTHFR gene (OMIM: 607093) plays an important role in the folate metabolism. It has been suggested that C677T (rs1801133) and A1298C (rs1801131) genetic polymorphisms in the MTHFR gene lead to the decreased activity of the methylenetetrahydrofolate reductase enzyme which may have significant effect on developing schizophrenia. W...

Recent literature suggests that the increasingly prevalent problem of substance abuse may have important implications for the symptoms and course of schizophrenia. To further examine the impact of substance abuse on this disorder, the clinical and research charts of 67 schizophrenic patients admitted to the Schizophrenia Program of the University of Michigan between 1987 and 1990 were reviewed ...

BACKGROUND Little is known about how chronic conditions other than prematurity, heart disease, and Down syndrome affect the risk and severity of hospitalization for respiratory syncytial virus (RSV). We assess the risk and severity of RSV hospitalization in children with chronic conditions in this register-based, population-based cohort study. METHODS Data on RSV tests, maternal smoking, sibl...

Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. A number of large scale genome wide association studies have identified numerous individual risk single nucleotide polymorphisms (SNPs) whose precise roles in schizophrenia remain unknown. Accumulation of many of these risk alleles has been found to be a more important risk factor. Consistently, recent studies showe...

BACKGROUND A single nucleotide polymorphism (SNP) within MIR137, the host gene for miR-137, has been identified repeatedly as a risk factor for schizophrenia. Previous genetic pathway analyses suggest that potential targets of this microRNA (miRNA) are also highly enriched in schizophrenia-relevant biological pathways, including those involved in nervous system development and function. METHO...

Epidemiologic studies indicate that nearly 60% of schizophrenia (SZ) patients treated with conventional antipsychotic drugs develop extrapyramidal side effects (EPS) such as parkinsonism and tardive dyskinesia. Although the prevalence of EPS has decreased due to the newer antipsychotics, EPS continue to limit the effectiveness of these medicines. Ongoing monitoring of EPS is likely to improve t...

BACKGROUND AND OBJECTIVE Patient characteristics require consideration for optimal treatment in order to achieve clinical remission for an improved quality of life and social functioning. Prior evidence supports long-acting injectable antipsychotics (LAIs) in the relapse prevention of schizophrenia. This study aimed to characterize Japanese patients diagnosed with schizophrenia and to compare t...

The validity of subtypes based on antisocial personality disorder (APD) or childhood conduct disorder without adult APD (CD only) in patients with schizophrenia (or schizoaffective disorder) and a substance use disorder (abuse or dependence) was examined. APD patients scored lower on personality measures related to socialization and higher on antisocial behavior, psychopathy, and aggression. AP...

We read with much interest Professor Bradford's comprehensive review on the role of serotonin in forensic psychiatry (J. M. W. Bradford, 24:57-72, 1996). He reviewed the literature on the treatment of primary paraphilias with selective serotonin reuptake inhibitors and the role of serotonin in disorders of sexuality. We would like to add [a note on] our experience with clozapine (a serotonin an...

background diarrheal infections are responsible for over a quarter of all childhood mortality worldwide. the present study was performed to establish risk factors for hospitalization of children with diarrhea in shahrekord, iran. materials and methods for this case-control study, cases were selected through children hospitalized due to acute diarrhea lasting less than 14 days and controls were ...