BACKGROUND AND OBJECTIVES Although widely used, serological typing of HLA loci does not always produce uequivocal results. This may be particularly the case for cord blood since samples may be of small volume and poor quality, and contaminated. DESIGN AND METHODS We typed 220 cord blood units (CBU) for HLA class I antigens using the serological technique. For those samples giving doubtful res...

Coeliac disease is an inflammation of the small intestine, occurring in genetically susceptible individuals triggered by the ingestion of gluten. Human Leukocyte Antigens (HLA) DQ2 and DQ8 gene have been identified as key genetic factors in coeliac disease as they are presented in almost 100 % of the patients. These genes are encoded by the combination of certain alleles in the DQA and DQB regi...

BACKGROUND The risk for type 1 diabetes mellitus (T1DM) and celiac disease (CD) is related to human leukocyte antigen (HLA) DQA1, DQB1 and DRB1 loci. Unfortunately, HLA typing has been too difficult and costly for frequent use. Automated genotyping focused on risk alleles could provide access to HLA typing in diagnostic evaluations, epidemiological screening and contribute to preventive strateg...

Recognition of HLA incompatibilities by the immune system represents a major barrier to allogeneic hematopoietic stem cell transplantation. HLA genotypically identical sibling donors are, therefore, the gold standard for transplantation purposes, but only 30% patients have such a donor. For the remaining 70% patients alternative sources of stem cells are a matched unrelated adult volunteer dono...

Human cytomegalovirus (HCMV) reactivation is a common complication after liver transplantation (LT). Here, we investigated whether human leukocyte antigen (HLA)-matching was related to HCMV infection and subsequent graft failure after LT for hepatitis B virus  cirrhosis. This retrospective study reviewed 91 LT recipients. All the patients were grouped according to HLA-A, HLA-B, and HLA-DR locus...

Dept. of Biology, Oncology and Genetics, Univ. Genova, Largo R. Benzi 10, 16132 Genova Italy Advanced Biotechnologies Center, Largo R. Benzi 10, 16132 Genova Italy Dept. of Computer Science, Univ. Pisa, Corso Italia 40, 56125 Pisa Italy National Institute for the Physics of Matter, Via Dodecaneso 33, 16146 Genova Italy Dept. of Computer and Information Science, Univ. Genova, Via Dodecaneso 35, ...

Minzhong Tang1, Jun Li2, Yulu Huang3, Yuming Zheng3 and Yonglin Cai2* 1College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, P.R. China 2Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou Red Cross Hospital, Guangxi, P.R. China 3Wuzhou Cancer Research Institute, Guangxi, P.R. China *Corresponding author: Ta...

OBJECTIVES To describe the incidence of hypersensitivity to abacavir and frequency of human leucocyte antigen (HLA)-B*5701 in HIV-infected Taiwanese persons. METHODS Medical records of 337 HIV-infected Taiwanese in whom abacavir-containing combination antiretroviral therapy (CART) was prescribed from 1 May 2001 to 31 December 2006 were reviewed, and HLA typing of the patients was performed in...

Background: Spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor. Objective: This case-control study was conducted to examine HLA- B27 positivity in patients with seronegative spondyloarthritis (SSA) as per ESSG criteria and compare the frequency with healthy controls because a lower positivity is rep...

Antibodies to antigens of the HLA system are formed by a proportion of women during a pregnancy and sometimes after blood transfusion. The gestational antibodies are of no significance to the pregnancy and in most cases they are thought to disappear from the serum a few weeks after termination of the pregnancy. They are, however, of great value as HLA typing reagents and most tissue typing labo...