HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule which has only limited polymorphism. It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA-A, HLA-B and HLA-C. This peptide binding is highly specific and stabilizes the HLA-E protein, allowing it to migrate to the cell surface. A functioning TAP (tra...

While the influence of HLA-AB and -DRB1 matching on the outcome of bone marrow transplantation (BMT) with unrelated donors is clear, the evaluation of HLA-C has been hampered by its poor serological definition. Because the low resolution of standard HLA-C typing could explain the significant number of positive cytotoxic T lymphocyte precursor frequency (CTLpf) tests found among HLA-AB-subtype, ...

We aimed to evaluate whether the HLA-G 14-base pair (bp) polymorphism (rs16375) has an impact on human immunodeficiency virus HIV progression and survival in an antiretroviral therapy-naive Zimbabwean cohort (n = 312). Rs16375 was genotyped using a competitive allele-specific polymerase chain reaction system; CD4 cell counts and HIV RNA were measured with flow cytometry and commercially availab...

Mosayebi M1, Dalimi Asl A2, Moazeni M3, Mosayebi Gh4 1. Ph.D Student, Department of Parasitology, Faculty of medicine, Tarbiat Modarres University 2. Professor, Department of Parasitology, Faculty of medicine, Tarbiat Modarres University 3. Professor, Department of Immunology, Faculty of medicine, Tarbiat Modarres University 4. Assistant professor, Department of Immunology, Faculty of medici...

Kidney transplantation is the therapy of choice for patients with end stage renal disease. Graft survival is optimal when donor and recipient are fully match for the human leukocyte antigens (HLA), however due to the high degree of polymorphism of HLA, in most situation, this is not possible. Therefore haploidentical (partially matched) siblings, parents or off-spring are considered as potentia...

Infection is involved at each of these points. Clinical observations implicate bacterial infection in ReA. The principal gene associated with spondyloarthropathy is HLA-B27, and infection is the driving force behind HLA polymorphism. Observations in ReA and animal models suggest a central role for bacteria in pathogenic mechanisms. This article reviews current understanding of spondyloarthropat...

HLA-DR3- and HLA-DRw52-associated functional polymorphism was investigated with selected tetanus toxoid (TT)-specific T cell clones. We have shown earlier that HLA-DR antigens are encoded by two distinct loci, DR beta I and DR beta III. The alloantigenic determinant(s) defined by the serological HLA-DR3 specificity map to the former, while the supratypic HLA-DRw52 determinants map to DR beta II...

the major histocompatibility complex (mhc) genes are the most polymorphic loci in the human genome and have been widely studied in various populations and ethnic groups. investigations into the hla genes and proteins have been useful tool for anthropological, transplantation and disease association studies. the polymorphism of the hla class i (a, b, c) and class ii (drb1, dqa1, dqb1) genes were...