The inhibitory 2DL1 and activating 2DS1 killer Ig-like receptors (KIR) both have shared ligand specificity for codon sequences in the C2 group HLA-Cw Ags. In this study, we have investigated NK cell activation by allogeneic target cells expressing different combinations of the HLA-KIR ligand groups C1, C2, and Bw4. We demonstrate that fresh NK cells as well as IL-2-propagated NK cells from 2DS1...

A new species of Stenolemus Signoret, 1858, Stenolemus annulatus sp. nov. (Reduviidae: Emesinae) is described from India. This new species is closely related to S. susainathani Wygodzinsky from Nilgiri Hills, South India and S. larat Wygodzinsky from Moluccas, Larat, by sharing common characteristics such as the ratio of distance between eyes and their width, long antennal first segment, slight...

In this study we determined TCR alpha and beta chain nucleotide sequences of HLA-Cw* 1601-restricted cytoxic T lymphocyte (CTL) clones obtained from the peripheral blood lymphocytes (PBL) of a melanoma patient. These clones were previously shown to be involved in the recognition of melanoma-associated antigenic epitopes SAYGEPRKL and AARAVFLAL encoded by gene MAGE-1 and BAGE respectively. All (...

Background and Aims: Human leukocyte antigen (HLA) molecules play a substantial role in T Lymphocyte-mediated adaptive immune response. Down-regulation of HLA expression may help the tumor to escape from immune surveillance. This study aimed to evaluate the correlation between HLA-G and HLA-E tissue distribution and the degree of tumor malignancy in human breast tumors. Materials and Methods:...

Amaç: Bu çalışmada, Sağlık Araştırma ve Uygulama Merkezi Doku Tipleme Laboratuvarına başvuran kişilerde HLA sınıf I II allel sıklığının belirlenmesi genotipleme sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç yöntem: Çalışmamızda toplam 1903 kişinin verileri incelenmiş sıklığı hesaplanmıştır. A, B DRB1 allelleri tüm örneklerde, C DQB1 alleleri 493 kişide çalışılmıştır. Değerlendirmeye alınm...