In this study we show that high molecular weight kininogen (HK) inhibited alpha-thrombin-induced aggregation of human platelets in a dose-dependent manner with complete inhibition occurring at plasma concentration (0.67 mumol/L) of HK. HK (0.67 mumol/L) also completely inhibited thrombin-induced cleavage of aggregin (Mr = 100 Kd), a surface membrane protein that mediates adenosine diphosphate (...

Playability” is measured for variations in a bowed-string simulation model. The variations studied are (1) the effect of torsion waves, and (2) the effect of the choice of friction model. It is found that (1) elimination of torsion-wave simulation does not degrade playability, and (2) the more recently developed “plastic” bowedstring friction model, in which the frictional force is a function o...

abstract the whole blood potassium concentration has shown the bimodal distribution in sheep, which has been classified into lk and hk types; hk allele is recessive to lk with a single gene inheritance. this polymorphism showed different behavior in different environment, which could be due to adaptation process. this research was conducted on the zel and kermani breed research station, which k...

We present a model describing friction due to the thermally activated formation and rupture of molecular bonds between two surfaces, with long molecules on one surface attaching to discrete or continuous binding sites on the other. The physical assumptions underlying this model are formalized using a continuum approximation resulting in a class of master-equation-like partial differential equat...

Within the normal human epidermis only Langerhans and indeterminate cells express HLA-DR. Human keratinocytes (HK), however, may also express HLA-DR in certain disease states characterized by mononuclear cell infiltrates. Previous studies have shown that HK synthesize HLA-DR in response to stimulation by interferon gamma (INF-gamma). The purposes of this study were to define conditions under wh...

Codina, Juan, Jian Li, and Thomas D. DuBose, Jr. CD63 interacts with the carboxy terminus of the colonic H -K -ATPase to increase plasma membrane localization and Rb uptake. Am J Physiol Cell Physiol 288: C1279–C1286, 2005. First published January 12, 2005; doi:10.1152/ajpcell.00463.2004.—The carboxy terminus (CT) of the colonic H -K -ATPase is required for stable assembly with the -subunit, tr...

Hexokinase is responsible for glucose phosphorylation, a process fundamental to regulating glucose uptake. In some tissues, hexokinase translocates to the mitochondria, thereby increasing its efficiency and decreasing its susceptibility to product inhibition. It may also decrease free radical formation in the mitochondria and prevent apoptosis. Whether hexokinase translocation occurs in the hea...

A model reference adaptive controller (MRAC) for compensating friction and payload uncertainties in a servopneumatic actuation system is presented in this paper. A friction model combining viscous and Coulomb friction is formulated within the framework of an adaptive controller. Due to the asymmetric nature of Coulomb friction in pneumatic piston actuators, a bi-directional Coulomb friction mod...

Friction appears in all mechanical systems and has a significant impact on control. Successful design of mechatronic systems requires an understanding of the effects of friction as well as techniques to compensation. Friction phenomena are complicated because they are caused by many different physical mechanisms. Friction can cause a substantial deterioration of the performance of a control sys...

OBJECTIVE The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and 18F-FDG accumulation in pancreatic cancer. METHODS Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received 18F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue a...