histones

The goal of this study was to examine fibril formation by the heterodimeric eukaryotic histones (H2A-H2B and H3-H4) and homodimeric archaeal histones (hMfB and hPyA1). The histone fold dimerization motif is an obligatorily domain-swapped structure comprised of two fused helix:β-loop:helix motifs. Domain swapping has been proposed as a mechanism for the evolution of protein oligomers as well as ...

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Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome

2017

Xin Lv Tao Wen Jiong Song Dong Xie Liang Wu Xuemei Jiang Ping Jiang Zongmei Wen

BACKGROUND Extracellular histones were recently identified as an inflammatory mediator involved in the pathogenesis of various organ injuries. This study aimed to examine extracellular histone levels and their clinical implications in acute respiratory distress syndrome (ARDS) patients and to explore histone-mediated effects through ex-vivo investigations. METHODS Extracellular histones, cyto...

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