A study was undertaken to fractionate and characterize the antidiabetic potential of Cyperus pangorei rhizomes. The column chromatography and HPTLC study was performed on ethyl acetate fraction and five sub-fractions were separated and subjected for the evaluation of antidiabetic potential in streptozotocin induced diabetic rats. The experimental data indicated that the ethyl acetate sub-fracti...

Cardiovascular diseases (CVDs) are still the principal cause of death worldwide. Weakened endothelial function followed by inflammation of the vessel wall hints at atheroscle-rotic lesion formation that causes myocardial infarction and stroke. Heart failure can arise as consequence of large myocardial infarctions. In its more severe stages, heart failure patients have a life anticipation that i...

Background: Recently herbal medications have been introduced into modern health scheme for the treatment of diseases. Aqueous extract of A. indica is commonly used in treatment of malaria in combination with chloroquine, especially now that a combined therapy is said to be more effective. Objectves: This study is designed to investigate the effects of aqueous extract of A. indica leaf and conco...

A crude 50% ethanol extract of Citrullus Colocynthis Schrad was administered orally to male albino rats for evaluation of antifertility effects. The animals were divided into five groups: group A was a vehicle-treated control group; treatment groups B, C, and D received 100 mg/kg/day C. Colocynthis extract for periods of 20, 40, and 60 days, respectively, and group E animals received the extrac...

Fluorescent dyes that stain a cell’s DNA are used in live cell imaging as they allow for tracking of cell division, for the visualization and sizing of dsDNA restriction fragments, and for the examination of properties of the isolated DNA molecules. Conventionally, Ethidium bromide (EtBr) is the cationic dye used to visualize DNA after separating the fragments on Agarose Gel Electrophoresis. It...

BACKGROUND Herbal medication is commonly employed in treatment of diseases. Aqueous extract of Azadirachta indica leaf (A. indica) is commonly used in treatment of malaria by Nigerians. Most often, aqueous extract of A. indica leaf is taken in combination with chloroquine in order to cure malaria infection without knowledge of the side effect especially by the rural dwellers in Nigeria. OBJEC...

Cirrhosis, a chronic liver disease, alters hepatic drug disposition; however, little is known about micromechanisms underpinning disease progression and how they contribute to changes in liver disposition properties. In this article, the authors present multilevel, agent-based and agent-directed In Silico Livers (ISLs) to probe plausible micro-mechanistic details for a cationic drug, diltiazem,...