Many biological and industrial processes have reactions which occur in thin zones of densely packed receptors. Understanding the rate of such reactions is important, and the BIAcore surface plasmon resonance biosensor for measuring rate constants has such a geometry. However, interpreting biosensor data correctly is difficult since large ligand molecules can block multiple receptor sites, thus ...

Research on the electro-oxidation of glutathione (GSH) may give insight into its real oxidation mechanism on biomembranes. In the present work, the unusual oxidation process of GSH on an Au electrode was probed by cyclic voltammetry (CV) technique. Voltammetric studies showed that –SH in GSH was the unique target of electro-oxidation by excluding the other potential oxidation sites (amido group...

In active learning, the learner uses its current knowledge to guide the choice of future training instances. This dependency between the agent's knowledge and its subsequent training set provides the active learner with a possibility for improved learning and at the same time a potential pitfall that can hinder learning. The opportunity for improved learning comes from choosing closely related ...

Dr. Goldhaber is associated with Brigham and Women’s Hospital, Harvard Medical School. Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (e-mail: [email protected]). Correspondence to: Samuel Z. Goldhaber, MD, FCCP, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 021...

Photocatalytic membranes exhibit great potential for water treatment since they combine the filtration and photo degradation in a single unit. Although blending photocatalytic nanoparticles into polymeric thin film remains the simplest method to prepare the photocatalytic membrane, the entrapped photocatalyst showed less catalytic activity due to the agglomeration and shielding effects in the p...

One hindrance to the development of fuel cells and electrolyzers are oxygen electrodes, which suffer from high overpotentials slow kinetics. Perovskite oxides have been shown be promisin...

Accepted for publication 14 March 1996. Systemic sclerosis (SSc) is a connective tissue disease characterised by an increased secretion of normal extracellular matrix proteins in mesenchymal tissue, and by widespread morphofunctional capillary abnormalities.' 2 Most of the clinical features of SSc are clearly related to vascular lesions; moreover, a diffuse microangiopathy is a prominent featur...

Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity. Like adherens junctions, desmosomes function as tumour suppressors and...