BACKGROUND Vascularized bone marrow transplantation (VBMT) is widely accepted as an efficient means of establishing chimerism and inducing tolerance. However, the mechanism underlying is poorly understood. Recently, regulatory T cells (Tregs) have been shown to play an important role in regulating immune responses to allogeneic antigens. In this study, we explored the role of Tregs in the induc...

OBJECTIVES Acute limb ischaemia is a common and often lethal clinical event. Reperfusion of an ischaemic limb has been shown to induce a remote gut injury associated with transmigration of endotoxin into the portal and systemic circulation, which in turn has been implicated in the conversion of the sterile inflammatory response to a sepsis syndrome, after lower torso ischaemia-reperfusion injur...

3D shape context is a method to define matching points between similar shapes. It can be used as a pre-processing step in a non-rigid registration. The main limitation of the method is point mismatching, which includes long geodesic distance mismatch causing wrong topological structure, and neighbors crossing mismatch between two adjacent points. In this paper, we propose a topological structur...

The technic for isolation-perfusion of the rat hind limb is described. By the stand ardized technic, limb viability was well maintained, and leakage of anticancer agents into the systemic circulation was negligible. The gross and microscopic response of the Walker 256 carcinosarcoma to perfusion with triethylenethiophosphoramide is de scribed. The preparation permits study of the many variables...

This case report assesses the role acupuncture played in the rehabilitation therapy of an African penguin with bilateral hind limb paresis and paralysis following egg binding and a caesarean section. Egg binding is the failure of the oviduct to pass the egg down into the cloaca. In avian species the sciatic nerve runs through the middle of the kidney. Swelling of the kidney tissue due to the pr...

This report describes fibrous cyst lining injection and extracorporeal shock wave therapy (ESWT) of a medial femoral condyle (MFC) subchondral cystic lesion (SCL) resulting in catastrophic MFC fracture in an Arabian mare. The mare was presented for evaluation of a severe hind limb lameness of approximately 4 months duration. On presentation, a non-weight bearing lameness of the left hind limb w...

Methods for long-term recording of peripheral nerve activity via intrafascicular electrodes have not been optimized. We compared the long-term functionality of custom-made 95%Pt/5%Ir intrafascicular electrodes containing a proximal spring-like structure to that of conventional straight electrodes. The modified electrode was implanted into the sciatic nerve fascicle of a random hind limb in 14 r...