IntroduCtIon Most hepatic biliary lesions are benign and incidentally discovered during procedures unrelated to the liver. Benign bile duct proliferations are gray–white subcapsular nodules that are often multiple, so it is not surprising that their detection results in more liver frozen sections than any other finding. In contrast, a diagnosis of intrahepatic cholangiocarcinoma is almost alway...

OBJECTIVE The aim of the present study is to determine if CEACAM6 can be detected in the bile of patients with biliary cancer and can serve as a diagnostic biomarker for cholangiocarcinoma. SUMMARY BACKGROUND DATA Distinguishing bile duct carcinoma from other diagnoses is often difficult using endoscopic or percutaneous techniques. The cell surface protein CEACAM6 is over-expressed in many ga...

Cholangiocarcinoma is the most common malignant bile duct and the second most common primary malignant tumor in the liver. It can be classified as intrahepatic (peripheral) or extrahepatic. Extrahepatic cholangiocarcinoma originate most often from the main hepatic duct and confluence (referred to as Klatskin tumor). The patients usually present with jaundice because of biliary obstruction. Prog...

The cholangiocarcinoma management is continually reviewed in the current evidence basis order to develop practice guidelines and consensus statements. However, standardized treatment are still unclear for patients who listed liver transplantation. We aimed validate evaluate potential efficacy of chemotherapy combination Gemcitabine Cisplatin as a neo-adjuvant prior In this prospective case seri...

Abstract Background Hilar cholangiocarcinoma is an aggressive cancer with poor prognosis. Complex pre-operative workup required prior to major surgery that frequently involves extended hepatectomy biliary reconstruction and associated high levels of post-operative morbidity mortality. Tools predict overall disease-specific outcome are better tailor pre-habilitation interventions selection patie...

AIMS It has been shown that nerve growth factor-β (NGF-β) promoted the initiation and progression of many tumors, and we have previously demonstrated that the expression of NGF-β was associated with tumor stage, nerve infiltration and lymph node metastasis in human hilar cholangiocarcinoma. However, whether NGF-β promotes tumor progression in human cholangiocarcinoma requires further investigat...