AIMS Various studies have reported a role of the serotonin transporter-linked polymorphic region (5-HTTLPR) in alcoholism. METHOD The present study investigated an association of this polymorphism with obsessive-compulsive alcohol craving in 124 male patients admitted for alcohol detoxification treatment. RESULTS We found significantly higher compulsive craving in patients with the long all...

OBJECTIVE This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. METHODS This st...

In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v) was investigated using the two-bottle free choice paradigm. To better understand the relations...

AIMS The present study explored whether specific single-nucleotide polymorphisms in alcohol metabolic pathway are associated with alcohol dependence or alcohol-related psychopathological symptoms. METHODS Three groups of male unrelated subjects were included: 101 currently alcohol-dependent patients, 100 formerly alcohol-dependent subjects and 97 healthy controls. The following questionnaires...

BACKGROUND The impact of alcohol use disorders (AUD) on psychological treatments for depression or anxiety in primary care psychological treatment services is unknown. AIMS To establish levels of alcohol misuse in an Improving Access to Psychological Therapies (IAPT) service, examine the impact of higher risk drinking on IAPT treatment outcomes and drop-out, and to inform good practice in wor...

Social conditions during rearing are well known to affect adult alcohol consumption, but few experiments have explored the effects of social conditions on behaviors that are related to alcohol dependence, such as the persistence of alcohol seeking. This study compared the effects of isolation (ISO) and interaction (INT) rearing on the persistence of alcohol-seeking behavior. Rats were trained t...

Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. The relationship between promoter methylation of genes involved in CRC carcinoge...

This investigation evaluates the effectiveness of UV-365 nm/S2O8 2process in degrading polyvinyl alcohol in aqueous solutions. The effects of pH, Na2S2O8 dosage, and temperature on the degradation efficiency of polyvinyl alcohol were studied. Under acidic conditions, the degradation efficiency of polyvinyl alcohol exceeded that under alkaline conditions. Additionally, a higher Na2S2O8 dosage an...