background: the incidence rate of breast cancer has been dramatically increasing since the last decade in iran, and it is now one of the most common female malignant tumors. b?cell lymphoma 2 (bcl2) family is the most important regulator of apoptosis, and ?938c>a single nucleotide polymorphism (snp) of bcl2 gene promoter has been demonstrated to influence breast cancer susceptibility. in this r...

OBJECTIVE This study explored whether average urinary estrogen metabolites in breast cancer high-risk women can be used to identify a subgroup of women at particularly high risk to develop breast cancer, to which prevention strategies should be addressed. METHODS The population consisted of 77 high-risk women, 30 breast cancer patients and 41 controls. All subjects answered a standardized que...

Background and Objective: Breast cancer is the second leading cause of cancer-related death in women. Better individualized treatment needs novel prognostic predictors. X-ray repair cross complementing XRCC5 and XRCC6 are coding genes of the Ku protein complex (key components of the non-homologous end-joining [NHEJ] pathway), which could serve as prognostic factors in breast cancer. Hence, in t...

background: il-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. over production of il-10 and elevated number of il-10 generating mononuclear cells in breast tumor tissue has already been shown. objective: to determine the association of il-10 promoter polymorphisms with increased risk of breast cancer and its association with breast cancer prognostic factors. methods: per...

Women with a family history of breast cancer have an increased risk of developing the disease. Women identified as "high risk" for developing breast cancer have been shown to exhibit increased levels of psychological distress and anxiety related to breast cancer. Oncology nurses can address this barrier and others, such as altered risk perception and lack of physician recommendation for screeni...

Breast cancer screening is essential in lowering breast-cancer related mortality and the prevalence of invasive and advanced breast cancer in high risk women. High risk women should receive a screening that is based on at least three imaging modalities, i.e. mammography, magnetic resonance imaging and ultrasonography, for the primary prevention of breast cancer. The use of these three modalitie...

Breast cancer screening is essential in lowering breast-cancer related mortality and the prevalence of invasive and advanced breast cancer in high risk women. High risk women should receive a screening that is based on at least three imaging modalities, i.e. mammography, magnetic resonance imaging and ultrasonography, for the primary prevention of breast cancer. The use of these three modalitie...

introduction accurate estimation of the skin-absorbed dose in external radiation therapy is essential to estimating the probability of secondary carcinogenesis induction materials and methods electron contamination in prostate radiotherapy was investigated using the monte carlo (mc) code calculation. in addition, field size dependence of the skin dose was assessed. excess cancer risk induced by...

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for a...

background & aim: family caregivers of cancer patients are at a high risk of physical, psychological and emotional problems, which could adversely affect their quality of life. this study aimed to evaluate the quality of life of the female caregivers of breast cancer patients in sabzevar, iran. methods: this cross-sectional study was conducted on 105 participants in sabzevar, iran in 2013. subj...