Vasopressin antagonist, which antagonizes pressor effect of vasopressin, was injected to spontaneously hypertensive rats under various conditions to observe whether arterial pressure was decreased to indicate secretion of pressor amounts of vasopressin. Vasopressin was secreted in pressor amounts in spontaneously hypertensive rats after acute spinal transection or sinoaortic denervation. This i...

ONE of the few observations made in hypertension upon which there is almost universal agreement is the increased response of the blood pressure to pressor drugs. It is found in nearly all types of hypertension, both experimentally and clinical.>9 Nevertheless, the mechanisms responsible for it have not been adequately investigated. I have studied the vascular reactivity in rabbits, comparing th...

Hexamethylenebistrimethylammonium (hexamethonium) iodide (C6) has been shown by Paton and Zaimis (1949) to exert a blocking effect at the synapses of autonomic ganglia. In a previous paper (Kay and Smith, 1950) we have shown that this compound, when given intramuscularly, inhibits the gastric secretion and motility. In the present paper we give the results obtained with the same drug administer...

Two cases of conjunctivitis caused by adenovirus type 34 (Ad34) are reported. The isolates were identified as Ad34 by the neutralization test and the PCR-sequence method of the hexon gene but as Ad14 by PCR-restriction fragment length polymorphism analysis. The genome types of these two isolates were identical to that of Ad34a.

The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus serotypes. However, chimeric modification of rAd5 hexon HVRs tends to cause low...

It is well known that the action of a drug on the intestinal movements in a particular species of animal depends on its functional autonomic innervation. In the present studies T EAC and Ca have been found to increase the rhythmic movements of the adult mongrel dog's intestine (in situ). The gut was subjected to vigourous circular contracractions but without the propulsive motility. These actio...

It has been known for many years that in certain cases of mitral stenosis the pulmonary arterial pressure may be disproportionately high. More recently it has been shown that this pressure, which is due to an increase in the pulmonary vascular resistance, may rise still further on effort (Bayliss et al., 1950; Eliasch et al., 1952). There is considerable debate as to the mechanism and significa...

[cited on 2008 Mar 28]. Available from: http://www. publicationethics.org/. 3. World Association of Medical Editors. [cited on 2008 Mar 28]. Available from: http://www.wame.org/. 4. Miller FG, Rosenstein DL. Reporting of ethical issues in publications of medical research. Lancet 2002;360:1326-8. 5. Bavdekar SB, Gogtay NJ, Wagh S. Reporting ethical processes in two indian pediatric journals. Ind...