Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods developed to separate heterogeneous gene expression rely on prior knowledge of the cell-type composition and/or signatures--these are not available in most public datasets. We present a novel method to identify the cell-type composition, signatures and proportions p...

Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown. Here we describe sequence m...

HnRNP (heterogeneous nuclear ribonucleoprotein) proteins are a large family of RNA-binding proteins that regulate numerous aspects of RNA processing. Interestingly, several paralogous pairs of hnRNPs exist that exhibit similar RNA-binding specificity to one another, yet have non-redundant functional targets in vivo. In this study we systematically investigate the possibility that the paralogs h...

We consider· the transport of the electric field temporal autocorrelation in heterogeneous, fluctuating turbid media. Experiments are performed in strongly scattering media with spatially separated static and dynamic components, and low resolution "dynamical" images of such media are obtained using autocorrelation measurements of the emerging speckle fields taken along the sample surface. Our a...

A beam experiment is presented to study heterogeneous reactions relevant to plasma-surface interactions in reactive sputtering applications. Atom and ion sources are focused onto the sample to expose it to quantified beams of oxygen, nitrogen, hydrogen, noble gas ions, and metal vapor. The heterogeneous surface processes are monitored in situ by means of a quartz crystal microbalance and Fourie...

This paper investigates the relationship between systems to enact software processes and systems to coordinate distributed, heterogeneous and concurrent objects. In particular, we describe in detail how one of these coordination systems systems—the “Coordination Language Facility” (CLF), developed at the Rank Xerox Research Centre—can be used to model and execute a sample software development p...

The potentially highly informative, but complex fluorescence decay of amino acids in protein is not fully understood and presents a barrier to understanding. Here we have tested a new and general approach to describing experimentally measured the fluorescence decay in a heterogeneous macroscopic sample. The decay parameters carry information on the features of the kinetics induced by the enviro...

Heterogeneous computing (HC) is the coordinated use of di€erent types of machines, net-works, and interfaces to maximize their combined performance and/or cost-e€ectiveness. HC systems are becoming a plausible technique for eciently solving computationally intensive problems. The applicability and strength of HC systems are derived from their ability to match computing needs to appropriate res...

The grid computing system can support the execution of computationally intensive parallel and distributive applications. The main characteristics of grid computing and heterogeneous computing system are similar. A novel scheduling algorithm, called NHEFT is proposed in this paper to enhance the functions of heterogeneous Earliest-Finish time (HEFT) algorithm. The NHEFT algorithm works for a bou...