نتایج جستجو برای: heterocycles
تعداد نتایج: 2986 فیلتر نتایج به سال:
Correction for ‘Recent developments in the solvent-free synthesis of heterocycles’ by Nilabrata Dey et al. , New J. Chem. 2023, https://doi.org/10.1039/d3nj01991h.
A photochemical ring expansion of 6- to 8-membered nitrogen heterocycles can be combined with a thermal aminocyclobutenones give efficient access azocines and benzoazocines.
Benjamin H. Rotstein,†,‡ Serge Zaretsky,† Vishal Rai,†,§ and Andrei K. Yudin*,† †Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario Canada, M5S 3H6 ‡Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 021...
M icrobes employ several catalytic strategies to transform conformationally f lexible peptide chains into rigidified scaffolds that possess antibiotic or toxin activity. Prominent examples include the biosynthesis of the -lactam antibiotics of the penicillin and cephalosporin families (1) and the maturation of vancomycin (2) where distinct structural modifications to the nascent peptide chains ...
Nitroenynes are an interesting electrophile in asymmetric organocatalysis, due to the versatility of functional groups present its structure. This review covers organocatalytic examples using this and application for synthesis chiral heterocycles.
Fused azolate ligands are hydrolytically-stable linkers for metal–organic frameworks. Their unique geometries and capacity functionalisation have opened new pathways at the convergence of simple N-heterocycles biologically relevant purines.
In recent years their has been an increased use of antifungal agents and has resulted in the development of resistance to drugs. Currently, use of standard antifungal therapies can be limited because of toxicity, low efficacy rates. Different types of mechanisms contribute to the development of resistance to antifungals. This has given raise to search for a new heterocycle with distinct action ...
One of the major challenges faced by organic chemistry is the efficient synthesis of increasingly complex molecules. Since October 2007, the Laboratory of Catalysis and Organic Synthesis (LCSO) at EPFL has been working on the development of catalytic reactions based on the Umpolung of the innate reactivity of functional groups. Electrophilic acetylene synthons have been developed using the exce...
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