Herpes simplex virus (HSV) keratitis is a common cause of ocular and visual morbidity. In this article, we systematically review published randomized clinical trials (RCTs) for HSV epithelial and stromal keratitis in order to establish a rational evidence-based foundation for treatment of these disorders. Articles for review were identified in the MEDLINE database from January 1, 1966, to May 3...

The authors have investigated the course of herpes simplex type 1 (HSV) keratitis in three different inbred strains of mice infected with four different HSV isolates. Severity of ocular disease and mortality is dependent upon both the virus isolate and the host strain. In particular, the likelihood of progression from self-limited dendritic keratitis to severe necrotizing stromal keratitis vari...

PURPOSE To use impression cytology to examine the structural changes in corneal epithelial cells infected with the herpes simplex virus in rabbit eyes. METHODS Corneal surfaces of 7 rabbits were scratched using a 25-gauge needle. Herpes simplex virus (type 1, Kos strain) was inoculated to the injured cornea. As the corneal diseases were observed using slit lamp biomicroscopy, impression cytol...

Treatment with idoxuridine (5-iodo-2'-deoxyuridine; I.D.U.) of experimental herpes simplex keratitis in rabbits (Kaufman, Nesburn, and Maloney, 1962; Corwin, Okumoto, Thygeson, and Jawetz, 1963) was followed by reports of its successful use in herpes simplex in man (Kaufman, Martola, and Dohiman, 1962; Corrigan, Gilkes, and Roberts, 1962; Havener and Wachtel, 1963 ; Maxwell, 1963). Other author...

despite advances in antiviral therapy over the past 2 decades, herpes simplex encephalitis (hse) remains a serious illness with significant risk of morbidity and mortality. hse includes a range of clinical presentations, from aseptic meningitis and fever to a severe rapidly progressive form with mental status changes (clouding of consciousness, confusion, disorientation, personality changes) an...

Systemic vaccination of rabbits with an inactivated type 1 virus subunit vaccine induced humoral and cell-mediated immune responses. Following ocular infection with type 1 herpes virus corneal ulceration and virus excretion were reduced in the vaccinated rabbits.

background and aims: several drugs are being used in treatment of hsv infection in human but still introducing an effective safe drug is desirable. methods: we investigated the inhibitory effect of morphine on replication of hsv in vitro. results: the results indicated that a concentration of up to 200 ug/ml morphine had a limited effect on vero cell viability. at this concentration the growth ...

Ocular disease caused by herpes simplex virus (HSV) 1 ranges in severity from a self-limiting blepharitis, conjunctivitis, or dendritic keratitis to a disciform stromal edema and necrotizing stromal keratitis that can cause blindness. Herpes keratitis and stromal disease are distinct, readily differentiable clinical entities that can be studied in animal models. In pure dendritic herpes keratit...

Background: Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic encephalitis, with significant morbidity and mortality that are effectively reduced by antiviral treatment. Herpes simplex infection in pregnant women rarely results in encephalitis. The most common symptoms of a pregnant woman with herpes simplex infection are colds and skin vesicles. Herpetic encephalitis...

Herpes keratitis is still considered to be one of the most serious diseases of the outer eye. With the advent of virostatics' in 1962 there has been progressive improvement in the treatment of dendritic keratitis. At present interferon treatment is at the centre of interest. It was discovered in 1957, but as it was very difficult to produce in large quantities experiments23 were limited. Studie...