A number of methods have been employed in attempts to induce encephalitis in guinea pigs with the Levaditi C strain of herpes virus. Some of these consisted of different modes of inoculation of the virus itself and others of different ways of combining it with vesicular stomatitis and neurovaccine viruses so as to obtain the concomitant effects of both. In still another test the Levaditi virus ...

BACKGROUND We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (HSE) from its mimics. METHODS We reviewed all adult cases of encephalitis with TL abnormalities on magnetic resonance imaging (MRI) from the California Encephalitis Project. We evaluated the association be...

Abstract A 39-year-old male without any preceding medical ailment presented with 12 day history of fever followed by behavioral changes left sided weakness. He was found to have Herpes Simplex Virus-1 encephalitis (polymerase chain reaction positive) and Magnetic Resonance Imaging finding asymmetrical frontotemporoparietal (right side affected more than side) involvement patchy enhancement atyp...

Encephalitis means inflammation of the brain. Acute encephalitis associated with viral infections includes two distinct clinical-pathological diseases. The form referred to simply as acute viral encephalitis is direct infection of neural cells with perivascular inflammation, neuronal destruction, neuronophagia, and tissue necrosis, and this pathology is centered primarily in the gray matter. Th...

In recent years, advances in the diagnosis and treatment of herpes simplex encephalitis (HSE) have been achieved due to the prevalence of antiviral drugs and the introduction of the polymerase chain reaction (PCR) to test the cerebrospinal fluid. The several clinical forms of herpes simplex virus type 1 (HSV-1) infections of the central nervous system (CNS), including acute disseminated encepha...

There is an cspccial fascination to the clinician attaching to a disorder which presents no single distinctive feature, which may simulate, or be simulated by, a large number of other affections, and in the recognition of which cytological, bacteriological, and chemical procedures have hitherto failed to afford any positive assistance. I may remind you that in the spring of 1917 von Economo5 di...

Today, with the advent of new medications, treatment of Ulcerative colitis (UC) has been markedly improved. Immunosuppressive drugs used in therapy predispose patients to opportunistic infections. A 22-year-old woman was admitted to emergency department due to acute exacerbation of UC and decreased level of consciousness. She was under treatment with 5-aminosalicylate, prednisolone and azathiop...

The guinea pig is subject to cerebral and corneal inoculation of the herpes virus. The effects of the inoculations vary with the strength or degree of virulence of the virus. Weak strains of the virus are implanted on the cerebrum with difficulty and strong strains with ease. Weak strains are quickly suppressed by the brain and strong strains may be passed indefinitely from brain to brain of th...

In this nationwide population-based cohort study using national Danish registries, in the period 1980-2008, our aim was to study employment and receipt of disability pension after central nervous system infections. All patients diagnosed between 20 and 55 years of age with meningococcal (n = 451), pneumococcal (n = 553), or viral (n = 1,433) meningitis or with herpes simplex encephalitis (n = 1...

PURPOSE The present study reports a case of encephalitis due to herpes simplex virus-1 (HSV-1), following surgical manipulation of the site of a primary infection. METHODS Herpes simplex virus-1 infection was confirmed by CSF PCR and DNA sequencing. RESULTS The patient was an 11-year-old girl who required temporal lobe surgery for epilepsy. She had meningoencephalitis due to HSV at the age ...