Medicinal plants have been used for decades for the treatment of different diseases. Solanum nigrum L is an important medicinal plant in many traditional health care systems. It has been used for the management of liver disorders, diabetes, infections, cancer, inflammations and peptic ulcer. In the present study, we screened the green unripe S. nigrum L fruits and leaves for their cytotoxic act...

improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. in the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, tween 20 a...

Received for publication, March 17,2011, and in revised form, June 1, 2011 Published,JBC Papers in Press, June 7, 2011, DOI10.1074/jbc.M111.240879 Rana Chattopadhyay*\ Patricia de Ia Vegac~.§, Sun H. Paik~, Yoko Murata\ Earl W. Ferguson~, Thomas L. Richie*11, and Guck T. Ooi From the* Malaria Program, United States Military Malaria Vaccine Program, §Walter Reed Army Institute of Research and th...

Three new bivalent nickel hydrazone complexes have been synthesised from the reactions of [NiCl(2)(PPh(3))(2)] with H(2)L {L = dianion of the hydrazones derived from the condensation of o-hydroxynaphthaldehyde with furoic acid hydrazide (H(2)L(1)) (1)/thiophene-2-acid hydrazide (H(2)L(2)) (2)/isonicotinic acid hydrazide (H(2)L(3)) (3)} and formulated as [Ni(L(1))(PPh(3))] (4), [Ni(L(2))(PPh(3))...

Iran has 1260 km of coastline that borders the Persian Gulf and the Oman Sea in the northwest Indian Ocean. Marine algae are one of the natural resources in the marine ecosystem which produce a wide range of new secondary metabolites with various biological activities that play an important role in the pharmaceutical care. In this study the cytotoxic activity of 28 marine algae of Chabahar coas...

BACKGROUND The incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, the indicated therapy for fungal control has limitations. Hence, medicinal plants have emerged as an alternative in the search for new antifungal agents as they present compounds, such as essential oils, with important biological effects. Published data dem...

Human tissue factor pathway inhibitor-2 (TFPI-2) is an extracellular matrix-associated Kunitz-type serine proteinase inhibitor that inhibits the plasmin- and trypsin-mediated activation of matrix metalloproteinases and inhibits tumor progression, invasion and metastasis. Previous studies have shown that TFPI-2 is downregulated in the progression of various tumors. The purpose of this study was ...

cancer is a major cause of death worldwide and causes serious problems in human life. it is developed by uncontrolled growth of a cell or a group of cells. there are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. the...

Zanthoxylum nitidum (Roxb.) DC is a traditional Vietnamese medicine to treat coughs, stomachache, toothache, blood stagnation, and sore throats. The essential oils (EOs) of the leaves, fruits, stems this plant were extracted by hydrodistillation subjected analysis gas chromatography (GC)-flame ionization detector (FID) GC-mass spectrometry (MS). isolated EOs then evaluated in terms their antimi...