OBJECTIVES Long non-coding RNA (lncRNA) associated with microvascular invasion in hepatocellular carcinoma (MVIH) has been recently reported to act as a predictor for the poor recurrence-free survival of hepatocellular carcinoma (HCC) after hepatectomy. However, the biological role of MVIH in the tumorigenesis of HCC is still unclear. METHODS In the study reported here, MVIH expression levels...

Background and AimsTo validate prognostic performance of the China liver cancer (CNLC) staging system as well to compare these parameters with those Barcelona Clinic Liver Cancer (BCLC) for Chinese hepatocellular carcinoma (HCC) treated transarterial chemoembolization (TACE).

Background Alpha-fetoprotein (AFP) is an oncofetal antigen expressed by over 50% of hepatocellular carcinoma (HCC) tumors. AFP-L3 is the major isoform present in the serum of HCC patients and is associated with poor patient prognosis. While HCC tumor-derived AFP (tAFP) contains >80% of AFP-L3, cord blood serum-derived AFP (nAFP) contains less than 5% of AFP-L3. Previous studies have proposed an...

Hepatocellular carcinoma (HCC) is the most common tumor in worldwide and chemotherapy resistant is a severe obstacle in HCC treatment. Annonaceous acetogenins was a nature compound from Uvaria accuminata and it has show the anti-tumor proliferation activity in many types cancer. In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepato...

Understanding the effects of inflammation and cirrhosis on regulation drug metabolism during progression hepatocellular carcinoma (HCC) is critical for developing patient-specific treatment strategies. Herein, novel 3D vascularized HCC chips (HCCoCs), composed HCC, endothelial, stellate, Kupffer cells tuned to mimic normal or cirrhotic liver stiffness, are created. controlled by tuning macropha...

When do you need to take biopsies of the liver, and what information will get is topic this review on hepatocellular carcinoma (HCC). If, clinically, differential diagnosis HCC after imaging suggested, a biopsy has become obligatory as diagnostic confirmation in non-cirrhotic liver prior definitive therapeutic interventions, well palliative therapy concept. In case hepatic lesions with an uncha...

Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the growth of hepatocellular carcinoma (HCC) cell lines and the molecular mechanisms involved. For this purpose, we performed cell proliferation assay by c...

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) has been speculated to play important roles in the development of several kinds of cancers. However, the role of WWP1 in hepatocellular carcinoma(HCC) is not clear. In the present study, we investigated the expression and prognostic role of WWP1 in primary hepatocellular carcinoma (HCC) using cell lines and 149 archived HCC samples. Corr...

Abstract Background Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. We aimed to identify new prognostic model of HCC based on differentially expressed (DE) immune genes. Methods The DE genes were identified an analysis 374 cases and 50 adjacent non-tumor specimens from the Cancer Genome Atlas (TCGA) database. Univariate Cox analysis, Lasso regression, multivariat...

BACKGROUND Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and thirdly leading cause of cancer-related death worldwide. The estimated risk of hepatocellular carcinoma is 15 to 20 times as high among persons infected with HCV as it is among those who are not infected, with most of the excess risk limited to those with advanced hepatic fibrosis or cirrhosis. Glypican3 (GPC3) pla...