Background and Aims: Both alcoholic drinks and high sugar-containing soft drinks cause major health problems worldwide. Oral administration of OS and M1 soy-derived extracts has been shown to alleviate liver injury in animal models. The aim of the present study was to determine the liver- and sugar-protective effect of OS and M1 soy-derived extracts when added to alcohol and sugar-enriched drin...

Objective: In this study the comparative hepato-protective efficacy of aqueous, ethanolic or benzene-acetone extracts of Butea monosperma (AEBM, EESC and BAEBM, respectively) were evaluated in carbon tetra chloride (CCl4) and isoniazid (INH) induced toxicity. Material & Method: For this, two parallel sets of experiments were performed. Hepatotoxicity was induced by either single dose of CCl4 or...

OBJECTIVE Whether or not selective visceral and renal perfusion during thoracoabdominal aortic aneurysm (TAAA) repair has a protective effect on visceral and renal function remains unknown. The aim of this study was to clarify if selective perfusion has such an effect. METHODS From May 1982 to December 1997, 82 consecutive patients underwent TAAA repair. Patients receiving hypothermic circula...

Consumption of a naturally occurring polyphenol, in moderate amounts, has been suggested to be beneficial to health. The present study investigated the efficacy of red wine on prevention of carbon tetrachloride (CCl4) induced acute hepatic injury in wistar rats. Hepatic damage due to CCl4 intoxication was assessed by employing biochemical parameters, markers of hepatic oxidative damage were mea...

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress....

Fucoidan, a sulfated polysaccharide extracted from various brown seaweeds, possesses a wide range of pharmacological properties. In this study, we investigated the protective effect of fucoidan on acetaminophen-induced acute liver injury in rats. Liver injury was induced by administration of acetaminophen (800 mg/kg, i.p.) and fucoidan was administered (100 mg kg, p.o.) 2 h before and after ace...

Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available. Wuzhi Tablet (WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepato-protective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This ...