literature review shows that hepatitis c infection may increase the risk of non-hodgkin lymphoma. reactivation of hepatitis b infection has been reported in patients with hairy cell leukemia after chemotherapy and/or splenectomy. we present hepatitis b surface (hbs) antigenemia and concurrent hepatitis c virus (hcv) seropositivity in a case of hairy cell leukemia. key words: hairy cell leukemia...

today, chronic viral hepatitis is considered as a public health problem in the world. totally, 5% of the world population, especially in asia and africa suffer from this problem. the prevalence of acute hepatitis in america is 0.1-0.2 percent, 50% of those with hepatitis c (hcv) and 5-10% of them with hepatitis b (hcv) develop chronic hepatitis. determining hbv and hcv genotypes is important to...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

OBJECTIVE To determine the frequency and pattern of Hepatitis B and C over the past twenty one years, in a liver research unit of Karachi. METHODS Retrospective analysis of the records of PMRC, Research Centre, Jinnah Postgraduate Medical Centre, Karachi, from 1987 to 2007 were reviewed. A special flow sheet was made where information of all patients with viral liver disease was entered. Pati...

results phylogenetic analysis of the partial ns5b region demonstrated the relatedness of isolate fsm165 to the new subtype reported from iran in 2006. moreover, some core/e1 and ns5b sequences that had a high level of similarity with fsm165 isolate were found through searching the hcv database. these sequences were previously either misclassified or could not be accurately classified. phylogene...

context from the 1970s till the mid 1990s, hepatitis b was the most common etiological factor for hepatocellular carcinoma (hcc) in pakistan. afterwards, a shift in hcc etiology was observed with a steady rise in hepatitis c virus (hcv) related hcc cases. hcv-3a, which is the most prevalent genotype, is also most frequent in hcv related hcc. there was an increase in the proportion of non-b non-...

introduction: the aim of this study is to assess the therapeutic efficacy and safety of a particular brand of ifn alpha (pdferon b®) in combination with ribavirin (rlba) on iranian patients with chronic hepatitis c (chc). the addition of riba to the standard treatment with interferon (ifn) alpha led to an improvement in sustained virologic response (svr) from less than 20% with ifn monotherapy ...

background evidence indicates that insulin resistance results in poor sustained viral response (svr) in patients with chronic hepatitis c (chc). metformin is an oral hypoglycemic agent which improves insulin resistance. methods we sought to determine if the addition of metformin to the treatment regimen could improve svr in treatment-naive chc patients in a randomized, double-blind, placebo-con...