background: coronary artery disease (cad) is one of the leading causes of death and disability around the world. interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . lipoprotein lipase (lpl) play an important role in the metabolism of hdl-c ( high density lipoprotein cholesterol ), ldl-c (low density lipoprotein ch...

Alcoholic liver disease (ALD) at early stages is characterized by hepatic steatosis, i.e., excessive accumulation of fat (e.g., triglyceride or triacylglycerol, esterified cholesterol) wrapped in lipid storage organelles called lipid droplets (LDs). While excessive hepatic steatosis can progress to more severe steatohepatitis or hepatocellular carcinoma in ALD, steatosis can be entirely reversi...

Lecithin-cholesterol acyltransferase deficiency is frequently associated with hypertriglyceridemia (HTG) in animal models and humans. We investigated the mechanism of HTG in the ldlr-/- x lcat-/- (double knockout (dko)) mice using the ldlr-/- x lcat+/+ (knock-out (ko)) littermates as control. Mean fasting triglyceride (TG) levels in the dko mice were elevated 1.75-fold compared with their contr...

Background: Coronary artery disease (CAD) is one of the leading causes of death and disability around the world. Interaction between genetic and environmental factors determines susceptibility of an individual to develop coronary artery disease . Lipoprotein lipase (LPL) play an important role in the metabolism of HDL-C ( High Density Lipoprotein Cholesterol ), LDL-C (Low Density Lipoprotein Ch...

PURPOSE Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. We aimed to clarify the impact of dietary walnut oil versus animal fat on hepatic steatosis, representing the initial step of multistage pathogenesis of NAFLD, in Zucker obese rats. METHODS Zucker lean ad libitum (a.l.), Zucker obese a.l. or Zucker obese pair fed (p.f.) to the lean receiv...