نتایج جستجو برای: heparan sulfate

تعداد نتایج: 59167  

Journal: :The Journal of biological chemistry 2005
Roberto Cappai Fang Cheng Giuseppe D Ciccotosto B Elise Needham Colin L Masters Gerd Multhaup Lars-Ake Fransson Katrin Mani

Processing of the recycling proteoglycan glypican-1 involves the release of its heparan sulfate chains by copper ion- and nitric oxide-catalyzed ascorbate-triggered autodegradation. The Alzheimer disease amyloid precursor protein (APP) and its paralogue, the amyloid precursor-like protein 2 (APLP2), contain copper ion-, zinc ion-, and heparan sulfate-binding domains. We have investigated the po...

Journal: :Journal of virology 2004
Masaru Tamura Katsuro Natori Masahiko Kobayashi Tatsuo Miyamura Naokazu Takeda

Norovirus (NV), a member of the family Caliciviridae, is one of the important causative agents of acute gastroenteritis. In the present study, we found that virus-like particles (VLPs) derived from genogroup II (GII) NV were bound to cell surface heparan sulfate proteoglycan. Interestingly, the VLPs derived from GII were more than ten times likelier to bind to cells than were those derived from...

Journal: :The Journal of Cell Biology 1993
D C Love J D Esko D M Mosser

The intracellular amastigote form of leishmania is responsible for the cell-to-cell spread of leishmania infection in the mammalian host. In this report, we identify a high-affinity, heparin-binding activity on the surface of the amastigote form of leishmania. Amastigotes of Leishmania amazonensis bound approximately 120,000 molecules of heparin per cell, with a Kd of 8.8 x 10(-8) M. This hepar...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1974
S Meier E D Hay

Previously, it was demonstrated that the embryonic corneal epithelium produces the chondroitin sulfate and heparan-sulfate-like compounds and the collagen of the primary corneal stroma. Synthesis of all of these extracellular materials is greatly enhanced in vitro when isolated epithelium is grown on collagenous substrata instead of Millipore filters. We report here that chondroitin sulfate, he...

Journal: :The Journal of biological chemistry 2005
Zhengliang L Wu Miroslaw Lech

The reducing end of heparan sulfate has been known for a long time, but information on the non-reducing end has been lacking. Recent studies indicate that the non-reducing end of heparan sulfate might be the place where fibroblast growth factor signaling complex forms. The non-reducing end also changes with heparanase digestion and, thus, might serve as a marker for tumor pathology. Using high ...

Journal: :Journal of cell science 1996
T Schaefer M Roux H W Stuhlsatz R Herken B Coulomb T Krieg H Smola

Contact of various cells with extracellular matrix molecules modulates their cellular functions and phenotype. Most investigations have employed dishes coated with purified matrix constituents or plain collagen I lattices omitting the effects of other important matrix components such as proteoglycans. In this study we analyze the effect of purified glycosaminoglycans (GAGs) on human fibroblasts...

Journal: :The Journal of biological chemistry 1977
B Radhakrishnamurthy H A Ruiz G S Berenson

Proteoglyeans from bovine aorta were extracted by 0.15 M NaCl and by digestion with collagenase and with elastase. The nonspecific protease activity of elastase was inhibited by soybean trypsin inhibitor. Glycosaminoglycans (GAG) of the proteoglycans were isolated, characterized, and quantitated. About 50% of the tissue chondroitin 4and B-sulfates, 75% of hyaluronic acid, and almost all chondro...

Journal: :Journal of Biological Chemistry 1997

Journal: :IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 2002

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