Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemi...

There are numerous ways of classifying the causes of anemia, and no one way is necessarily superior to another. It is equally important to appreciate the differences in the approaches to diagnosis between children and adults, men and women, and persons of different ethnic backgrounds. Regardless of the specific algorithm followed in evaluating anemia, it is essential that easily remediable caus...

OBJECTIVES To present a case of acute brucellosis triggering acute hemolytic anemia in a subject with glucose-6-phosphate dehydrogenase (G6PD) deficiency. CLINICAL PRESENTATION AND INTERVENTION A 17-year-old male patient presented with fever, malaise and jaundice. His blood and bone marrow cultures yielded Brucella species. In addition, he was found to have acute hemolytic anemia due to previ...

background autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. most of the cases are associated with viral or bacterial infections. in some cases, aiha can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. case report especially in children younger than 2 y...

BACKGROUND Accumulating evidence suggests that transfusion of packed red blood cells (PRBCs) stored for >14 days is associated with increased rates of sepsis, multiple organ dysfunction, and mortality in human patients. OBJECTIVE To determine if duration of PRBC storage has an effect on morbidity and mortality in dogs after transfusion. ANIMALS Dogs admitted to the Matthew J Ryan Veterinary...

The evaluation of prosthetic valves can provide a unique challenge, and a thoughtful approach is required. High output states like anemia should be kept in the differential when evaluating elevated gradients across prosthetic valves. We present the case of a 69-year-old man with a Starr-Edwards prosthetic aortic valve who presented with symptoms of congestive heart failure and high transvalvula...

L AYRISSE, LINARES, AND ROCHE in 19651 demonstrated that there is a reduction in the survival of radiochromium ( 51Cr) and di-iso-pro-pylfluoro-phosphonate (32DFP)-tagged red cells from subjects with marked iron deficiency anemia#{176} associated with hookworm infection. They observed that these erythrocytes also had a short survival when they were injected in normal recipients and nearby norma...