Background: Children affected with sickle cell disease (SCD) are at increased risk for severe morbidity and mortality, especially during the first 3-5 years of life. It is suggested that early treatment can improve the condition. The aim of this pilot study was to estimate the incidence of hemoglobin S (HbS) by umbilical cord blood screening in Khorramshahr and Abadan cities in southwest of Ira...

The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blo...

We demonstrate kinetically that the reaction of 5,5V-dithiobis(2-nitrobenzoate) with the CysF9[93]h sulfhydryl group of domestic cat hemoglobins is a reversible process. In the major hemoglobin, in which the NH3 + terminal group of GlyNA1[1]h is free, kf, the apparent forward second order rate constant, has a complex pH dependence profile. In the minor hemoglobin, the NH3 + terminal group of Se...

The aim of the study was to determine the factors associated with resting and exerciseinduced hemoglobin oxygen desaturation. The well-established 6-minute-walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the 6-minute-walk test. Blood sa...

the effect of intravenous and oral iron administration on responsiveness to synthetic erythropoietin in treatment of hemodialysis patients' anemia     shariati ar [1] , asayesh h [2] , mojerloo m [3] , karimi taleghani h [4]     received: 10june, 2011 accepted: august 28, 2011     abstract   background & aims : inadequate production of erythropoietin is the main cause of anemia in chronic ...

Sickle cell disease affects more than 100,000 individuals in the United States, among whom disease severity varies considerably. One factor that influences disease severity is the sickle cell disease genotype. For this reason, clinical prevention and treatment guidelines tend to differentiate between genotypes. However, previous research suggests caution when using a claimsbased determination o...

Rothschild B M, Sienknecht C W, Kaplan S B, Spindler J S. Sickle cell disease associated with uric acid deposition disease. Ann Rheum Dis 1980; 39: 392-5. 2 Ballou S P, Khan M A, Kushner I, Harris J W. Secondary gout in hemoglobinopathies: report of two cases and review of the literature. Am J Hematol 1977; 2: 397-402. 3 Crosby W H. The metabolism of hemoglobin and bile pigment in hemolytic dis...

  Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted within 20 months, from May 2005 to December 2006, in order to evaluate the efficacy of PDpoetin (rh-EPO...