The aim of this present study is to evaluate the therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells (SCs) and bone marrow stromal cells (BMSCs) on a rat model of spinal cord hemi-section injuries (Brown-Séquard syndrome), which is relevant to human clinical spinal cord injury. Both in vivo and in vitro data we received demonstrated that co-transplantation BMSCs w...

Treatments for spinal cord injury may promote new spinal cord synapses. However, the potential for new synapses between descending somatomotor and spinal sympathetic neurons has not been investigated. We studied rats with intact spinal cords and rats after a chronic, bilateral, dorsal spinal hemisection. We identified sympathetically related spinal neurons by transynaptic, retrograde transport ...

Introduction: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional reha...

Spinal cord injury (SCI) is a complex disease that affects not only sensory and motor pathways below the neurological level of (NLI) but also all organs systems situated this NLI. This multisystem impairment implies comprehensive management in dedicated SCI specialized centers, by interdisciplinary multidisciplinary teams, able to treat impairment, affected. After brief history Cord Medicine, a...

Background: Urodynamics is the gold standard for evaluating function of neurogenic bladder after spinal cord injury (SCI), but there are few studies on urodynamics in patients with complete and incomplete suprasacral SCI different periods.There a lack sufficient evidence timing first urodynamic examination.

Spinal cord injury (SCI) is characterized by damage resulting in dysfunction of the spinal cord. Hydrogels are common biomaterials that play an important role treatment SCI. biocompatible, and some have electrical conductivity compatible with tissues. a high drug-carrying capacity, allowing them to be used for SCI through loading various types active substances, drugs, or cells. We first discus...

cell therapy is known as one of the most promising curative interventions in the spinal cord injury (sci). selection of an appropriate route to transplant the stem cells is very important. principally, four different injection routes have been used in animal experiments. 1. intramedullary route: this route is known as a classic method for transplantation of stem cells. in this method, the stem ...

background: health-related quality-of-life (hr-qol) may be affected by various factors including injury-related characteristics among individuals with spinal cord injury (sci). however, the impact of the influence of these variables has not yet been fully described in iranian population. here, we assessed the relationships between injury-related characteristics and hr-qol among iranian people w...

We examined the effect of muscle basal lamina (MBL) with neural stem cells (NSCs) and olfactory ensheathing cells (OECs) on spinal cord injury repair. Seventy-two Sprague-Dawley rats were subjected to spinal cord hemisection and divided into 6 groups. In blank control group (group A), the ends of the spinal cord hemisection model were flushed with physiological saline. In NSC transplantation gr...