Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin. mTOR activates p70S6K, which controls translation of mRNA to generate prote...

Cavernous hemangioma of the lung synonymous with arteriovenous fistula or aneurysm of the lung is generally considered to be a congenital abnormality. According to Lindskog and Liebow,1 at least 60 cases are in the literature. Roentgenologically, cavernous hemangioma has the appearance of a lobular shadow of increased density continuous with hilar vascular shadows. Clinically it is usually asso...

Hemangioma of infancy is a condition that may be associated with significant morbidity. While evidence most supports the use of corticosteroids, there is no well-defined or Federal Drug Administration (FDA)-approved systemic therapy for hemangioma of infancy. All currently used treatments have significant risks. Dramatic improvement of complicated hemangioma of infancy to propranolol was recent...

Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typically occurring in young or middle-aged persons. It is usually apparent as a ...

Submit Manuscript | http://medcraveonline.com mobile, non-tender and adherent to the skin. The lesion was completely blanchable on pressure with a glass slide, thus giving an appearance of hemangioma clinically. There was no punctum on the surface of the lesion (Figure1). With a differential diagnosis of hemangioma ,a doppler ultrasonography of the lesion was performed which rather than suggest...

ocal splenic lesions are rare, occurring with a frequency of about 0.2% on sonography.1 Hemangiomas are the most common primary benign neoplasms of the spleen, with prevalence ranging from 0.3% to 14% at autopsy.2–4 On gray scale sonography, a splenic hemangioma may show the typical appearance described for a liver hemangioma (a hyperechoic lesion with well-defined margins with or without poste...

PURPOSE To report a case of orbital capillary hemangioma in an adult who was successfully treated with topical timolol maleate 0.5% solution. METHODS Case report. RESULTS A 43-year-old female presented both superficial and deep orbital capillary hemangioma. Topical timolol maleate was applied twice daily. The superficial lesions have nearly disappeared after 1 year of treatment. The deeper ...

OBJECTIVE: To describe a case of a congenital hepatic hemangioma treated with surgery. METHODS: We report the case of a 6-day-old boy who presented a giant hepatic hemangioma, and describe its evolution. RESULTS: The child developed hemodynamic instability secondary to consumption coagulopathy and respiratory failure. The image studies were inconclusive. He was submitted to surgery with complet...

Renal hemangioma is an uncommon benign tumor which usually causes painless or painful gross hematuria. Its preoperative diagnosis is extremely difficult or even impossible. We experienced three cases of renal hemangioma, located mainly at the pelvocalyceal junction or in the inner medulla. US demonstrated variable echogenecity, and CT revealed a lack of significant enhancement. Where there is g...

A case of intramuscular hemangioma of the right forearm and hand muscle is presented in this study. This tumor may infiltrate the muscle and be misdiagnosed as a malignant neoplasm. The patient, a 14-year-old girl, presented to the clinic with right forearm and hand pain and swelling which began when she was 2 years old and had been gradually increasing in size. Because the mass might have been...