The objective of this study was to the synergistic antitumor effect lipophilic bismuth nanoparticles (BisBAL NPs) with antibiotic solution Neo-Poly gramicidin on human cervical tumor cells. BisBAL NPs and cancer cell line (HeLa) determined by MTT viability assay fluorescence microscopy. After a 24-h exposure 0.1× HeLa growth decreased 94%. Fluorescence microscopy confirmed death higher among tr...

Purpose: To delve into the related molecular mechanism of suppressor cytokine signaling 4 (SOCS4) on cervical cancer cell proliferation and migration. Methods: Quantitative real-time polymerase chain reaction western blot assays were employed to examine SOCS4 mRNA or protein expression in four human line (HeLa, SW-732, AV3, CaSki) normal epithelium immortalized (H8) MTT viability applied verify...

• Quinoline-based BODIPYs as potential EGFR/VEGFR-2 inhibitors. Lipinski's drug likeness of compounds 1–3 revealed promising physicochemical properties for oral bioavailability. The interaction was examined by molecular docking with binding energies in the order 3˃2˃1. HOMO and LUMO were also calculated using DFT method. vitro anticancer activity 1 3 on HeLa cells evaluated. This paper reports ...

Allium hirtifolim (Persian Shallot) belongs to Allium genus (Alliaceae family). We investigated the in vitro effects of chloroformic extract of A. hirtifolium and its Allicin on the proliferation of HeLa (cervical cancer), MCF7 (human, caucasion, breast, adenocarcinoma) and L929 (mouse, C3H/An, connective) cell lines. Our results showed that components of A. hirtifolium might inhibit proliferat...

A series of dehydroabietic acid (DHAA) acyl-thiourea derivatives were designed and synthesized as potent antitumor agents. The in vitro pharmacological screening results revealed that the target compounds exhibited potent cytotoxicity against HeLa, SK-OV-3 and MGC-803 tumor cell lines, while they showed lower cytotoxicity against HL-7702 normal human river cells. Compound 9n (IC50 = 6.58 ± 1.11...

Anti-tumor activity of the proteins from Gecko (GP) on cervical cancer cells, and its signaling mechanisms were assessed by viable cell counting, propidium iodide (PI) staining, and Western blot analysis. GP induced the cell death of HeLa cells in a dose-dependent manner while it did not affect the viability of normal cells. Western blot analysis showed that GP decreased the activation of Akt, ...