Acosta, Glen Howel. M.S., Purdue University, August, 2014. Susceptibility of Parkinson’s Disease Following Mild Blast Traumatic Brain Injury. Major Professor: Riyi Shi, M.D., Ph.D. Blast injury-induced neurotrauma (BINT) is steadily increasing in prevalence due to escalated terror activity and constitutes the signature injury associated with current military conflicts. BINT produces significant...

Thyrotropin-releasing hormone (TRH) and certain TRH analogs show substantial neuroprotective effects in experimental brain or spinal cord trauma but also have other physiological actions (autonomic, analeptic, and endocrine) that may be undesirable for the treatment of neurotrauma in humans. We developed a novel TRH analog (2-ARA-53a), with substitutions at the NH2-terminus and imidazole ring, ...

The one-year birth cohort of 12 058 children, 96% of all children born in the two northernmost provinces of Finland, Oulu and Lapland, in 1966 was studied prospectively up to the age of 14 years. During this period 14 children, 1.2 per thousand, were lost from the follow-up. Data on development, mortality, and morbidity were collected prospectively by means of questionnaires and from various re...

905 Dear Editor: We read with great interest the careful study by Dr. Reichard and his colleagues (Reichard RR, White CL, Hladik CL, Dolinak D. Beta-amyloid precursor protein staining of nonaccidental central nervous system injury in pediatric autopsies. J. Neurotrauma 2003;20: 347–355). The paper provides some valuable information about the neuropathology of fatal infant head injury. It confir...

PRIMARY OBJECTIVE Clinical management of acute traumatic brain injury (TBI) has emphasized identification of secondary mechanisms of pathophysiology. An important objective in this study is to use proton magnetic resonance spectroscopy (pMRS) to examine early metabolic disturbance due to TBI. RESEARCH DESIGN The current design is a case study with repeated measures. METHOD AND PROCEDURE Pro...