Cancer is a global public health problem; it causes great loss of life and responsible for enormous economic, social emotional burdens [1,2]. In head neck, cancer includes variety neoplasms.

BACKGROUND The aim of this study was to develop and validate a symptom inventory for patients with head and neck cancer and to assess the occurrence and severity of symptoms, the overall symptom burden, and the interference the symptoms cause in daily life. METHODS Items were generated from a comprehensive literature review, our prior work, and focus groups with head and neck cancer patients,...

Before CDDP was clinically used, combination chemotherapy regimens like BLM + MMC, VCR + MTX-LV + BLM, VCR + MTX-LV + BLM + MMC had been used for recurrent tumors of the head and neck. In a phase II study with CDDP, we experienced two patients with long-term survival (12, 15+) who were treated with CDDP as a second-line chemotherapy for recurrent tumors. Cisplatin was evaluated as a potentially...

Head and neck cancer is the 5th most common cancer in the world with half a million new cases reported globally every year, 44,600 within the United States. Up to 40% of head and neck cancer patients will eventually die because of it. With half of patients having an advanced stage of disease upon initial diagnosis. Squamous cell carcinoma contributes to 95% of head and neck cancers. Squamous ce...

BACKGROUND Epidemiological association of head and neck cancer with smokeless tobacco (ST) emphasizes the need to unravel the molecular mechanisms implicated in cancer development, and identify pharmacologically safe agents for early intervention and prevention of disease recurrence. Guggulsterone (GS), a biosafe nutraceutical, inhibits the PI3K/Akt pathway that plays a critical role in HNSCC d...

Ming Gao1, Minghua Ge2, Qinghai Ji3, Ruochuan Cheng4, Hankui Lu5, Haixia Guan6, Li Gao7, Zhuming Guo8, Tao Huang9, Xiaoming Huang10, Xiaoming Li11, Yansong Lin12, Qinjiang Liu13, Xin Ni14, Yi Pan15, Jianwu Qin16, Zhongyan Shan6, Hui Sun17, Xudong Wang1, Zhengang Xu18, Yang Yu1, Daiwei Zhao19, Naisong Zhang20, Sheng Zhang21, Ying Zheng22, Jingqiang Zhu23, Dapeng Li1, Xiangqian Zheng1, Chinese As...

Locally advanced head and neck cancers are usually treated with concurrent chemoradiation. The residual nodes after chemoradiation in such patients are a common scenario, but the further investigation and treatment options in form of neck dissection are still not very clear. This review focuses on the current state of available evidence in literature for management of such patients and directs ...

OBJECTIVES To investigate missed appointments in a South African tertiary hospital. STUDY DESIGN Prospective, descriptive series with controls. SETTING The ENT/Oncology clinic at Tygerberg Academic Hospital, South Africa. SUBJECT 305 patients with a head and neck malignancy who had follow-up appointments over 4 consecutive months between June and September 2006. A control group of 31 pati...

Head and neck cancer is a major public health problem. In the United States alone, approximately 43,000 new cases of head and neck cancer will be diagnosed and 11,000 persons will die of the disease in 1993 (1, 2). Worldwide, over 500,000 new cases of this cancer occur yearly, and the incidence is rising. Furthermore, despite intensive efforts in primary prevention, screening, and therapy, long...

Cancer cell lines are the basic material for various lines of cancer research. Diverse cancer cell lines derived from tissues of various head and neck regions are needed for biological research on head and neck cancer. However, cell lines derived from cancer of the head and neck are not common. Recently, we established and characterized a novel human squamous carcinoma cell line, CNUH-HNSCC-1. ...