introduction and aims: although a few studies have done in our country in the field of hepatitis d, its risk factors are not clearly known. this study was conducted with the aim of assessing the relative frequency and risk factors of hdv and the correlation between hdv and severity of liver damage. materials and methods: this was a cross sectional study. 280 hbsag positive subjects (including 1...

The Miyako Islands, located in the southernmost part of Japan, have been reported to be endemic for hepatitis delta virus (HDV). The majority of HDV patients in this area exhibit a relatively mild course of infection that evolves into a quiescent cirrhotic condition. The entire nucleotide sequence of the Miyako isolate (L215) of HDV obtained from a cirrhotic patient infected with HDV was determ...

The hepatitis delta virus (HDV) is a rarest form of viral hepatitis, but has the worst outcomes for patients.It is a subviral satellite dependent on coinfection with hepatitis B (HBV) to replicate within the host liver.To date, there has been little to no modeling effort for HDV. Deriving and analyzing such a mathematical model poses difficulty as it requires the inclusion of (HBV). Here we beg...

Hepatitis delta virus (HDV) is the smallest known human and causes most severe form of viral hepatitis, yet it still not fully understood how replicates interacts with many host proteins during replication. This review aims to provide a systematic all factors currently interact HDV their mechanistic involvement in steps replication cycle. Finally, we discuss implications for therapeutic develop...

Two forms of hepatitis delta antigen (HDAg) have different roles in the replication cycle of hepatitis delta virus (HDV); the small forms trans activates HDV RNA replication, whereas the large form suppresses it but is needed for virion assembly. To understand the mechanism of these regulatory activities, we studied the possible HDAg oligomerization and its role in HDV replication. In this repo...

Assembly of hepatitis delta virus (HDV) in infected human hepatocytes involves association of the 1,679- nucleotide single-stranded genomic RNA (deltaRNA) with multiple copies of both small and large forms of the delta protein (deltaAg) to form a ribonucleoprotein particle which in turn interacts with envelope proteins of the natural helper virus, hepatitis B virus. Subsequently, for initiation...

STUDY OBJECTIVE The hepatitis delta virus (HDV) contributes significantly to the morbidity and mortality of hepatitis B virus (HBV) infection, which is particularly prevalent among intravenous drug users and male homosexuals. A recent report has indicated that HDV first appeared in the South East London intravenous drug using population in 1982. The aim of the present study was to assess the pr...

Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B (HBV). Dual HDV/HBV infection associated with down-regulated HBV replication and fast progression to severe liver disease. Although HDV transmissible through exposure infected blood, data about in blood donors remain scarce. Between 2011 2021, 869,633 donations were collected from prequalified Dalian, China. In total, 1060 (0.1...

BACKGROUND Hepatitis B virus (HBV) and hepatitis D virus (HDV) represent important public health problems in the Western Amazon region with reported cases of fulminant hepatitis. This cross sectional study describes HBV and HDV genotypes circulating in the Brazilian Amazon region. METHODS HBsAg positive individuals (n = 224) were recruited in Manaus/Amazonas State (130 blood donors from the H...

background hepatitis delta virus (hdv) is dependent on the hepatitis b virus for transmission and propagation. based on isolated hdv sequences from different parts of the world, at least three major different genotypes with different geographic distributions are suggested. studies have shown that genotype 1 is the predominant genotype of hdv in different parts of iran; however, the genotype dis...