The recent development by Craig (l-3) of an all-glass machine for liquidliquid counter-current fractionation makes possible the application of his method to the separation of porphyrins which cannot readily be separated by the sensitive Willstatter “HCl number” method. In this paper we have studied the application of the Craig method to the separation of a mixture of three known porphyrins, usi...

Hairy cell leukemia (HCL) and HCL-like disorders, including HCL-variant, are disorders of heterogeneous mature lymphoid B-cells known for their hairy infiltration accompanied by a specific genetic profile, various clinical presentations, and, as they uncommon hematological malignancies characterized pancytopenia, the need appropriate therapy. Sometimes HCL creates diagnostic challenges clinicia...

OBJECTIVE Fabry disease is a rare X-linked disease caused by mutations to the GLA gene, resulting in a deficiency of the lysosomal enzyme alpha-galactosidase A. This study evaluated the pharmacokinetics, safety, and tolerability of ascending single doses of oral migalastat hydrochloride (HCl), an investigational drug, in healthy Japanese volunteers. METHODS In this phase I, randomized, placeb...

BACKGROUND Mechanical ventilation is necessary during acute respiratory distress syndrome, but it promotes lung injury because of the excessive stretch applied to the aerated parenchyma. The authors' hypothesis was that after a regional lung injury, the noxious effect of mechanical ventilation on the remaining aerated parenchyma would be more pronounced. METHODS Mice, instilled with hydrochlo...

Characterization of the interaction of hydrogen chloride (HCl) with polar stratospheric cloud (PSC) ice particles is essential to understanding the processes responsible for ozone depletion. The interaction of HCl with ice was studied using a coated-wall flow tube with chemical ionization mass spectrometry (CIMS) between 5x10(-8) and 10(-4) Torr HCl and between 186 and 223 K, including conditio...

This paper describes ab initio electronic structure calculations on the planar transition states of 2-chloropropene leading to HCl elimination in the ground electronic state to form either propyne or allene as the cofragment. The calculations provide optimized geometries of the transition states for these two reaction channels, together with vibrational frequencies, barrier heights, and reactio...

PURPOSE Two individual phase 3 conjunctival allergen challenge (CAC) studies of similar design have assessed the efficacy and safety of olopatadine hydrochloride (HCl) 0.77% for the treatment of allergic conjunctivitis. The purpose of this study is to evaluate the integrated efficacy and safety of olopatadine HCl 0.77% from a larger dataset by pooling data from the two individual CAC studies. ...

Bolus i.v. injections of 1.2 N HCl elicit a rapid but transient pulmonary vasoconstriction in broiler chickens. In mammals, the pulmonary vasoconstrictive response to bolus acid injection depends on increased synthesis of thromboxane A2; however, the vascular responsiveness of domestic fowl to thromboxane previously had not been evaluated. In the present study, we tested the hypothesis that, if...

alpha-Interferon (IFN-alpha) induced unique ultrastructural alterations in peripheral blood and splenic hairy cell leukemia (HCL) cells (14 of 20 cases) treated in vitro. To further investigate the effects of B-cell growth factor (BCGF) and IFN-alpha on target hairy cells (HCs), we utilized immunogold labeling in conjunction with scanning electron microscopy. This methodology, in contrast to ot...

Epirubicin HCl is a new anthracycline analog and derivative of doxorubicin. Doxorubicin is a potent anticancer agent, the use of which is limited by its cumulative dose-dependent cardiotoxicity. Epirubicin HCl has more favorable therapeutic index than doxorubicin and possesses less hematologic and cardiac toxicity at comparable doses. Hepatoma G2 cells are a valuable model to study hepatocellul...