Hybrid cache architecture (HCA), which uses two or more cache hierarchy designs in a processor, may outperform traditional cache architectures because no single memory technology can deliver the optimal power, performance and density at the same time. The general HCA scheme has also been proposed to manage cache regions that have different usage patterns. However previous HCA management schemes...

Dentin hypersensitivity (DH) is a painful response to stimulus applied to the open dentinal tubules of a vital tooth. It's a common oral condition, however, without an ideal treatment available yet. This work evaluated in vitro the effect of micron-sized particles from a novel bioactive glass-ceramic (Biosilicate) in occluding open dentinal tubules. A dentin disc model was employed to observe c...

Human carbonic anhydrase II (HCA II) has a histidine at position 64 (His64) that donates a proton to the zinc-bound hydroxide in catalysis of the dehydration of bicarbonate. To examine the effect of the histidine location on proton shuttling, His64 was replaced with Ala and Thr200 replaced with histidine (H64A-T200H HCAII), effectively relocating the proton shuttle residue 2 A closer to the zin...

Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O mechanism to catalyze the reversible hydration of CO2. This catalysis also involves a separate proton transfer step, mediated by an ordered solvent network coordinated by hydrophilic residues. One of these residues, Tyr7, was previously shown to be deprotonated in the neutron crystal structure at pH 10. This observation indicated th...

A molecular and pathological classification system for hepatocellular adenomas (HCAs) was recently introduced in Europe, resulting in four major identified subgroups. Asian countries have a considerably lower incidence of HCA as well as a different etiology. We aimed to characterize HCAs in a Chinese population based on this new classification system. A series of 30 patients with HCA were analy...

Objective: To evaluate the shortand long-term outcomes among very low birth weight (VLBW) preterm infants after histologic chorioamnionitis (HCA). Methods: We performed a retrospective analysis of 5849 single infants (birth weight51500 g) born at a gestational age between 22+ 0 and 33+ 6 weeks. Clinical data were obtained from the Neonatal Research Network Japan between 2003 and 2007. Multivari...

OBJECTIVES To evaluate the outcome in elderly patients (≥ 75 years) undergoing elective aortic arch surgery with the aid of selective antegrade cerebral perfusion (SACP) and moderate hypothermic circulatory arrest (HCA). METHODS A series of 95 patients ≥ 75 years (median age 77 years, median EuroSCORE 28) undergoing elective aortic arch surgery with SACP and moderate HCA were analysed with re...

In many mammalian species, prenatal stress masculinizes female and feminizes male offspring impairing their reproductive capacity. Regrouping gestating sows is a common, stressful production practice, but its impact on the developing pigs of the sow is not fully known. This study examined the effects of regrouping gestating sows and the administration of exogenous glucocorticoids on the growth ...

Using a hollow cathode assembly (HCA) in a large vacuum chamber, such as the University of Michigan's Large Vacuum Test Facility (LVTF), provides the capability of generating a plasma environment that closely approximates that of the ionosphere. This capability allows examinations of ionospheric-plasma phenomena in a controlled setting without, in most cases, relying on scaling techniques. The ...

The role of the health-care assistant (HCA) has developed rapidly in general practice and has occurred on an ad hoc basis across the UK, with the precise role shaped by the requirements and culture of individual practices. Currently, there is no regulation of HCAs and little published material about the remit of the role. This study aimed to describe general practice colleagues' perceptions of ...