Interferon alfa (IFN-alpha) treatment is effective in only a proportion of patients with chronic hepatitis B virus (HBV) infection. The mechanisms for therapeutic failure remain unknown but high levels of HBV replication are known to inhibit the immunopotentiating effects of IFN-alpha. In nine patients with chronic hepatitis B not responding to IFN-alpha monotherapy, we determined the virus-spe...

hepatitis b virus (hbv) is the most prevalent viral infection and is among the leading causes of human liver diseases. nearly 360 millions of people are world widely infected with prolonged forms of hepatitis b including active and inactive chronic forms. chronic hepatitis b (chb) is associated with cirrhosis and hepatocellular carcinoma (hcc) in patients suffering from congenital and/or acquir...

we read with a great interest the article written by davoodbeglou and colleagues entitled “evaluation of hepatitis b infection prevalence in institutionalized intellectually disabled children” which is recently published in your prestigious journal 1 . the authors concluded that hbv infection is more prevalent among institutionalized disabled children and that we should change our health polici...

Hepatitis B virus (HBV) infects more than 300 million people worldwide and is a common cause of liver disease and liver cancer. HBV, a member of the Hepadnaviridae family, is a small DNA virus with unusual features similar to retroviruses. HBV replicates through an RNA intermediate and can integrate into the host genome. The unique features of the HBV replication cycle confer a distinct ability...

Although substance abuse treatment programs are important contact points for providing health services for hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, availability of services in these programs has not been well characterized. This study evaluated the spectrum of HBV and HCV services offered by substance abuse treatment programs within the National Drug Abuse Treatment Clini...

Results The results of this study demonstrate that hepatitis E virus (HEV-RNA) infection to be rare (6.25%) in HBVDNA positive cases. Surface antigen (HBsAg) for hepatitis B virus was positive in 18 cases (45%) and IgM Anti HEV was positive in 16 cases (40%). Hepatitis B virus infections, as the predominant causes of liver diseases, HBV-DNA was detected in 32 cases out of 40 cases and HEV-RNA w...

background oxidative stress plays a major pathogenic role in liver injury following chronic hepatitis b. glutathione peroxidase (gpx) has a central role in regulating the oxidative state. hepatitis b virus (hbv) results in down-regulation of gpx. on the other hand, iron homeostasis is disrupted in hbv infected patients. therefore, the objective of this study was to assess the interplay of gpx a...

Hepatitis outbreaks in hemodialysis (HD) patients and staff were reported in the late 1960s, and a number of hepatotropic viruses transmitted by blood and other body fluids have been identified. Hepatitis B virus (HBV) was the first significant hepatotropic virus to be identified in HD centers. HBV infection has been effectively controlled by active vaccination, screening of blood donors, the u...

background : hepatitis b virus (hbv) is one of the most popular causes of chronic liver diseases through the world. there are approximately 350 million individuals infected with the hbv that 15 to 20 million of them are co-infected with hdv. it is known that co-existent infection with hdv tends to accelerate the progress of chronic hbv infection to chronic hepatitis, cirrhosis and hepatocellula...

Hepatitis B virus (HBV), a small and economically packaged double-stranded DNA virus, represents an enormous global health care burden. In spite of an effective vaccine, HBV is endemic in many countries. Chronic hepatitis B (CHB) results in the development of significant clinical outcomes such as liver disease and hepatocellular carcinoma (HCC), which are associated with high mortality rates. H...