OBJECTIVE To determine the effect of self-experience multidisciplinary lifestyle intervention on health care providers (HCPs), patients and clinics. METHODS We randomized 15 primary-care clinics (serving 93,821 members), matched by patient profile, to provide the HCPs, either intervention or control HMO program. We followed personally 77 HCPs and 496 patients, and evaluated clinical measureme...

In a structure-activity relationship (SAR) study, 3-methoxy-1,4-phenanthrenequinones, calanquinone A (6a), denbinobin (6b), 5-OAc-calanquinone A (7a) and 5-OAc-denbinobin (7b), have significantly promising cytotoxicity against various human cancer cell lines (IC(50) 0.08-1.66 µg/mL). Moreover, we also established a superior pharmacophore model for cytotoxicity (r = 0.931) containing three hydro...

The effect of glycemic control on the prognosis of nondiabetic patients after acute myocardial infarction (AMI) remains uncertain. We investigated whether glycated hemoglobin (HbA1c) is associated with adverse outcomes after AMI in nondiabetic patients. In this observational study, we enrolled nondiabetic patients with AMI in the emergency department of 2 medical centers from January 2011 to Se...

Alpha thalassemia (α-thal) is relatively common worldwide. Most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. The hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. The aim of this study was to compare hematologic features...

Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether hi...

METHODS: Pharmacists conducted assessments of patients’ glycemic control (HbA 1c), blood pressure (BP), lipid levels (total cholesterol, low-den sity lipoprotein [LDL], high-density lipoprotein [HDL], triglycerides), and body mass index (BMI). The therapeutic goals were: HbA1 c less than 7%, BP lower than 130/85 mmHg, total cholesterol under 200 mg/dl, LDL less than 100mg/dl, HDL lower than 45 ...

UNLABELLED In this study we intended to determine serum level of the carcinoembryonic antigen (CEA) and to find out the correlation with oxidative stress parameters among diabetic female in comparison to control subjects. METHODS A total of 120 Saudi (type 2 diabetic "T2DM", n = 60 and healthy non-diabetic, n = 60) nonsmokers females were enrolled in this study. Body mass index (BMI) was esti...

OBJECTIVE The metabolically healthy obesity (MHO) phenotype is an important obesity subtype in which obesity is not accompanied by any metabolic comorbidity. However, the underlying molecular mechanisms remain elusive. In this study, a shotgun proteomics approach to identify circulating biomolecules and pathways associated with MHO was used. METHODS The subjects were 20 African-American women...

The U.K. Prospective Diabetes Study (UKPDS) demonstrated that intensive glucose control with insulin or sulfonylureas markedly reduces the risk of microvascular complications (1). For myocardial infarction, the reduction in risk (16% for a 0.9% decrease in HbA1c) was of borderline significance but corresponded closely to epidemiological predictions (14% decrease for a 1% drop in HbA1c) (2). The...