Two haemoglobins have been described that do not contain ac-chains: haemoglobin H (Rigas, Koler & Osgood, 1955, 1956; Gouttas, Fessas, Tsevremis & Xefteri, 1955) consists of four fA-polypeptide chains (Jones, Schroeder, Balog & Vinograd, 1959), and haemoglobin Bart's (Ager & Lehmann, 1958) consists of four yF-polypeptide chains (Hunt & Lehmann, 1959). These two abnormal haemoglobins are now ref...

Increasing the expression of the gamma globin genes is considered a useful therapeutic approach to the beta globin diseases. Because butyrate and alpha-amino-n-butyric acid (ABA) augment gamma globin expression in normal neonatal and adult erythroid progenitors, we investigated the effects of sodium butyrate and ABA on erythroid progenitors of patients with beta thalassemia and sickle cell anem...

Hyperbilirubinemia (HB) occurs in 90% of preterm newborns. Moderate HB can induce acute neurological disorders while severe HB has been linked to a higher incidence of apneas of prematurity. The present study aimed to test the hypothesis that even moderate HB disrupts cardiorespiratory control in preterm lambs. Two groups of preterm lambs (born 14 days prior to term), namely control (n = 6) and...

PURPOSE To assess hemoglobin (Hb) outcomes and fatigue-related quality-of-life (QoL) (electronic assessment) in patients with solid tumors and symptomatic chemotherapy-induced anemia receiving cytotoxic chemotherapy and darbepoetin alfa (DA) or another erythropoiesis-stimulating agent according to European indication. METHODS eAQUA was a Phase IV prospective observational study. The primary o...

The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been asso...

By L. JUDEN REED, THOMAS B. BRADLEY, JR. AND HEu N M. RANNEY F ETAL HEMOGLOBIN, a tetramer of 2a and 2y polypeptide chains, constitutes the major hemoglobin component in newborn infants. During the first 6 months of extra-uterine life, the synthesis of y chains declines as chain synthesis increases. Adult Hb A, a tetramer of 2a and 2$ polypeptide chain accounts for over 95 per cent of the hemog...

By PHAEDON FESSAS F EW EXAMPLES of erythrocytic inclusions due to abnormalities of the hemoglobin molecule are known. The first concerns Hb H.”2 Although the precipitates of Hgb H, such as is observed in the usual test employing brilliant cresyl blue, are produced artificially, there is evidence that some are formed spontaneously in vivo.’4 The second example is that of Hb Zurich; the precipita...

Introduction. The primary purpose of the present paper is to express the Mth order intrinsic derivative of a higher order absolute tensor such as T, Tab, or T$ as a contraction of extensors. As a first step, we develop a rule for constructing extensors of the types E'fi\ Eaa.pi» E°e;¥a from absolute tensors T , Tab, T% by repeated differentiation with respect to the curve parameter followed by ...

The standard reduced bar complex B(A) of a differential graded algebra A inherits a natural commutative algebra structure if A is a commutative algebra. We address an extension of this construction in the context of E-infinity algebras. We prove that the bar complex of any E-infinity algebra can be equipped with the structure of an E-infinity algebra so that the bar construction defines a funct...