نتایج جستجو برای: hb f induction

تعداد نتایج: 511260  

Journal: :The Biochemical journal 1963
N DANCE E R HUEHNS G H BEAVEN

Two haemoglobins have been described that do not contain ac-chains: haemoglobin H (Rigas, Koler & Osgood, 1955, 1956; Gouttas, Fessas, Tsevremis & Xefteri, 1955) consists of four fA-polypeptide chains (Jones, Schroeder, Balog & Vinograd, 1959), and haemoglobin Bart's (Ager & Lehmann, 1958) consists of four yF-polypeptide chains (Hunt & Lehmann, 1959). These two abnormal haemoglobins are now ref...

Journal: :Blood 1989
S P Perrine B A Miller D V Faller R A Cohen E P Vichinsky D Hurst B H Lubin T Papayannopoulou

Increasing the expression of the gamma globin genes is considered a useful therapeutic approach to the beta globin diseases. Because butyrate and alpha-amino-n-butyric acid (ABA) augment gamma globin expression in normal neonatal and adult erythroid progenitors, we investigated the effects of sodium butyrate and ABA on erythroid progenitors of patients with beta thalassemia and sickle cell anem...

2016
Marie-Laure Specq Mélisande Bourgoin-Heck Nathalie Samson François Corbin Christian Gestreau Maxime Richer Hazim Kadhim Jean-Paul Praud

Hyperbilirubinemia (HB) occurs in 90% of preterm newborns. Moderate HB can induce acute neurological disorders while severe HB has been linked to a higher incidence of apneas of prematurity. The present study aimed to test the hypothesis that even moderate HB disrupts cardiorespiratory control in preterm lambs. Two groups of preterm lambs (born 14 days prior to term), namely control (n = 6) and...

2016
Jean-Loup Mouysset Beata Freier Joan van den Bosch Charles Briac Levaché Alain Bols Hans Werner Tessen Laura Belton G Chet Bohac Jan-Henrik Terwey Giuseppe Tonini

PURPOSE To assess hemoglobin (Hb) outcomes and fatigue-related quality-of-life (QoL) (electronic assessment) in patients with solid tumors and symptomatic chemotherapy-induced anemia receiving cytotoxic chemotherapy and darbepoetin alfa (DA) or another erythropoiesis-stimulating agent according to European indication. METHODS eAQUA was a Phase IV prospective observational study. The primary o...

رشیدی قادر , فریبا, کوثریان , مهرنوش,

Background and purpose: Hydroxy urea lowers the severity of anemia in patients with thalassemia by increasing Hb F but may cause negative effects on heart due to high Ô2 affinity of Hb F. Materials and methods : This descriptive study was performed on patients with thalassemia receiving Hydroxyurea during a five year period in thalassemia ward at Booali Hospital. Ïnclusion criteria were n...

2012
Aldo Villalón Mauricio Sepúlveda Néstor Guerrero Margarita M. Meynard Karina Palma Miguel L. Concha

The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been asso...

Journal: :Blood 1965
L J REED T B BRADLEY H M RANNEY

By L. JUDEN REED, THOMAS B. BRADLEY, JR. AND HEu N M. RANNEY F ETAL HEMOGLOBIN, a tetramer of 2a and 2y polypeptide chains, constitutes the major hemoglobin component in newborn infants. During the first 6 months of extra-uterine life, the synthesis of y chains declines as chain synthesis increases. Adult Hb A, a tetramer of 2a and 2$ polypeptide chain accounts for over 95 per cent of the hemog...

Journal: :Blood 1963
P FESSAS

By PHAEDON FESSAS F EW EXAMPLES of erythrocytic inclusions due to abnormalities of the hemoglobin molecule are known. The first concerns Hb H.”2 Although the precipitates of Hgb H, such as is observed in the usual test employing brilliant cresyl blue, are produced artificially, there is evidence that some are formed spontaneously in vivo.’4 The second example is that of Hb Zurich; the precipita...

2007
HOMER V. CRAIG

Introduction. The primary purpose of the present paper is to express the Mth order intrinsic derivative of a higher order absolute tensor such as T, Tab, or T$ as a contraction of extensors. As a first step, we develop a rule for constructing extensors of the types E'fi\ Eaa.pi» E°e;¥a from absolute tensors T , Tab, T% by repeated differentiation with respect to the curve parameter followed by ...

2007
BENOIT FRESSE

The standard reduced bar complex B(A) of a differential graded algebra A inherits a natural commutative algebra structure if A is a commutative algebra. We address an extension of this construction in the context of E-infinity algebras. We prove that the bar complex of any E-infinity algebra can be equipped with the structure of an E-infinity algebra so that the bar construction defines a funct...

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