BACKGROUND Approximately 268,000 Fidelis leads were implanted worldwide until distribution was suspended because of a high rate of early failure. Careful analyses of predictors of increased lead failure hazard are required to help direct future lead design and also to inform decision making on lead replacement. We sought to perform a comprehensive analysis of all potential predictors in a multi...

OBJECTIVE It was aimed to review the literature and make a meta-analysis of the trials on both upfront, switching, and sequencing anastrozole in the adjuvant treatment of early breast cancer. METHODS The PubMed, ClinicalTrials.gov and Cochrane databases were systematically reviewed for randomized-controlled trials comparing anastrozole with tamoxifen in the adjuvant treatment of early breast ...

In many pharmaceutical studies, non-inferiority clinical trials are usually conducted because of the difficulty of finding a therapy that has more superior efficacy than a recognized effective one. When planning the non-inferiority clinical trials with a time-to-event endpoint, the calculation of sample size is one of the most fundamental steps. A proper sample size provides reasonable power to...

A class of random hazard rates, which is defined as a mixture of an indicator kernel convolved with a completely random measure, is of interest. We provide an explicit characterization of the posterior distribution of this mixture hazard rate model via a finite mixture of S-paths. A closed and tractable Bayes estimator for the hazard rate is derived to be a finite sum over S-paths. The path cha...

A class of random hazard rates, that is defined as a mixture of an indicator kernel convoluted with a completely random measure, is of interest. We provide an explicit characterization of the posterior distribution of this mixture hazard rate model via a finite mixture of S-paths. A closed and tractable Bayes estimator for the hazard rate is derived to be a finite sum over S-paths. The path cha...

Risk estimation in radiation carcinogenesis depends primarily on epidemiological data and hazard rate models. The A-bomb survivors follow-up provides information on the complexity of this process. Several hazard rate models are briefly discussed and illustrated using the A-bomb experience.

Does the Hazard Rate for New Plants vary between Lowand High-Tech Industries?* Based on a longitudinal data base the hazard rate of over 12,000 newly established plants in U.S. manufacturing industry in 1976 are estimated and then compared between low and high-tech industries. It is found that the hazard rate differs across industries, and it also varies between lowand hightech industries. The ...

This paper investigates the demand elasticity of search. We provide a new characterization of monotone hazard rate and of the first-order condition determining the optimal reservation price, and prove that the demand for information is elastic if the hazard rate function h for the distribution of offers is decreasing and inelastic if h is increasing.  2000 Elsevier Science S.A. All rights rese...