Scaffolds play a pivotal role in the tissue engineering paradigm by providing temporary structural support, guiding cells to grow, assisting the transport of essential nutrients and waste products, and facilitating the formation of functional tissues and organs. Single-walled carbon nanotubes (SWNTs), especially ultra-short SWNTs (US-tubes), have proven useful for reinforcing synthetic polymeri...

BACKGROUND AND OBJECTIVE Periodontal disease is a common infectious disease, found worldwide, causing the destruction of the periodontium. The periodontium is a complex structure composed of both soft and hard tissues, thus an agent applied to regenerate the periodontium must be able to stimulate periodontal ligament, cementum and alveolar bone regeneration. Recent studies demonstrated that ace...

cellular manufacturing system is one of the most important applications of group technology. design of this system involves many structural and operational issues, in which the cell formation and production planning are two important steps. in this paper, a new mathematical model is proposed for integration of cell formation and production planning problems with the aim of minimizing the overal...

OBJECTIVES The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA). MATERIALS AND METHODS Eighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine,...

Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins known as fusogens are responsible for mediating membrane fusion. However, until recently, these proteins either remained unidentified or were poorly understood at the mechanistic level. Here, we review how fusogens surmount multiple energy barriers to mediate cell-cell fusion. We describe how early prepara...

and The National Graduate School for Biomaterials and Tissue Engineering ACADEMIC DISSERTATION To be publicly discussed with the permission of the Medical Faculty of the University of Helsinki, in the large lecture hall (Iso luentosali) Work hard and try your best! If you then fail I am not angry.-my father-This thesis is based on the following original publications. They are referred to in the...

 Dental implants, as a result of their excellent success rates and advantages over fixed or removable methods, have become the optimal treatment for replacing missing teeth. Surgical and restorative techniques that can reduce the loss of hard and soft tissues that often accompany implant placement are desirable. Achieving an esthetic outcome in tooth replacement and implant treatment requires a...

Microparticles are membrane vesicles released from many different cell types. There are two mechanisms that can result in their formation, cell activation and apoptosis. In these two mechanisms, different pathways are involved in microparticle generation. Microparticle generation seems to be a well regulated process. Microparticles vary in size, phospholipid and protein composition. They have a...