Albrecht introduced the concept of hamartoma at beginning twentieth century to designate a tumor like or non-neoplastic malformation inborn error tissue development. They arise virtually in all organs. may derive from any three germinal layer which mesodermal derived overgrowth is most common. are slow growing and have self-limited growth. The formation these growth take place by abnormal mixin...

Lymphangiomas are hamartomatous lymphatic mutations that happen when tissue is sequestered at few areas not associated with channels. Lymphatic malformations of the head and neck, additionally called lymphangiomas or cystic hygromas, a diverse group lesions. The majority present birth, 90% developing before age two. As much as 75% these arise within neck region less frequently stated oral cavit...

A 63-year-old male with history of prostate cancer treated with radiation presented for a colonoscopy for small volume hematochezia. The colonoscopy revealed numerous polyps, which were found to be ganglioneuromas on histological examination. He was referred to medical genetics with suspicion for hamartomatous polyposis syndrome and was found to have a mutation in the PTEN gene. Based on this a...

Adenomatoid Odontogenic tumor (AOT) is a benign (hamartomatous) lesion of Odontogenic origin, which is relatively uncommon and affects young individuals with a female predominance, mainly in the second decade. This lesion is most commonly located i the anterior maxilla and is usually associated with an impacted canine tooth. The present case report is a 15year old female patient, who presented ...

Cowden syndrome (CS) is a genetic disorder characterized by multiple benign tissue growths (i.e., hamartomas) and an increased risk of developing specific cancers, such as breast, thyroid, kidney, endometrial, or colorectal cancer (Genetics Home Reference, 2012). This genetic syndrome was named after a person diagnosed with the disorder (Lloyd & Dennis, 1963). CS is part of a larger syndrome ca...

Macrodystrophia lipomatosa is a rare congenital nonhereditary developmental anomaly. It is characterized by hamartomatous proliferation of the soft tissue leading to disproportionate enlargement of the limbs and digits. Since it leads to diagnostic dilemma, it has to be differentiated from various other conditions as they differ in course, prognosis, complications, and treatment. Herein, we pre...