PURPOSE Cancers of biliary system represent highly malignant diseases of dismal prognosis. We have previously introduced AxdAdB3, an E1A, E1B double-restricted oncolytic adenovirus, which showed excellent oncolytic efficacy for approximately half of the biliary cancer lines with an enhanced safety to normal cells. The purpose of this study was to evaluate whether RGD-fiber modification (AxdAdB3...

Cortisol awakening response (CAR) has been studied in children with ADHD, and some authors have reported morning cortisol differences among ADHD subtypes. Despite, only half of the children with ADHD continue to exhibit the disorder into adulthood, CAR has not been studied in adults so far. One hundred and nine adults with ADHD according to the DSM-IV criteria (46 inattentive and 63 combined) r...

Semi-active Fuzzy control of quarter car system having three degrees of freedom and assembled with magnetorheological (MR) shock absorber is studied in present paper. First, experimental work was performed on an MR shock absorber under different excitation conditions to obtain force-displacement and force-velocity curves. Then, for the application of experimental data in semi-active quarter car...

This year’s American Society of Hematology (ASH) Annual Meeting (December 2016, San Diego, USA) had an emphasis on leukemia and adoptive therapy, as did previous ASH meetings. But this year, ASH also had a dedicated session on “Adoptive Immunotherapy: CAR-T Toxicity and Clinical Trials”, and experience with chimeric antigen receptor (CAR) T-cell therapy in various clinical trials to date was pr...

Driver behavior plays an important role in modeling vehicle dynamics in a traffic simulation environment. To study one element of the general driver behavior, that of car following, an advanced instrumented vehicle has been applied in dynamic data collection in real traffic flow on Swedish roads. This paper briefly introduces our car following data collection and smoothing methods. Moreover, we...

Chimeric-antigen-receptor (CAR) T cells targeting CD19 show dramatic remissions in refractory or relapsed acute lymphoblastic leukemia. Interleukin-6 (IL-6) has been associated with severe cytokine release syndrome (CRS) following CAR T cell treatment, leading to significant toxicity and death. CRS could be treated with an antiIL6-receptor antibody, with reversal of most of the inflammatory res...

This paper aims at exploring the use of sentiment analysis on social media as a tool for sales forecasting in the automotive industry. Previous research on this topic has presented significant results although current literature still lacks investigation on the usefulness of this technique when it comes to more expensive items. In particular, about 500,000 social media posts and eleven car mode...

NONLINEAR DYNAMICS OF LONGITUDINAL GROUND VEHICLE TRACTION By Brian John Olson The purpose of this study is to investigate and understand the nonlinear dynamics of longitudinal ground vehicle traction. Specifically, the performance of rubber-tired automobiles under straight-ahead braking and acceleration conditions is discussed in detail. Two vehicle-traction models are considered—a quarter-car...

Private cars are valued not just for their functionality but also the freedom, autonomy or status they offer. New research quantifies value individuals assign to car ownership and shows that more than half of it derives from non-use value.